Effects of a Physical Exercise Program on Cerebral and Hepatic Hemodynamics in Patients With Cirrhosis. (Pilot Study)

Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran0 sites28 target enrollmentFebruary 1, 2016

ConditionsCirrhosis Portal Hypertension Exercise

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Cirrhosis
Sponsor: Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Enrollment: 28
Primary Endpoint: Improvement in neurocognitive status-1
Status: Completed
Last Updated: 3 years ago

Overview Investigators Eligibility Criteria Outcomes Similar Trials

Overview

Brief Summary

This study evaluates the effects of a structured exercise (The LFN-exercise protocol) program plus diet, on cerebral hemodynamics (cerebral blood flow) and hepatic hemodynamics (portal pressure), as well as on nutritional status (body composition and nutritional markers) in order to facilitate the prescription of exercise in patients with cirrhosis.

Registry

clinicaltrials.gov

Start Date

February 1, 2016

End Date

January 31, 2020

Last Updated

3 years ago

Study Type

Interventional

Study Design

Parallel

Sex

All

Investigators

Sponsor

Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran

Responsible Party

Sponsor

Eligibility Criteria

Inclusion Criteria

•Liver cirrhosis of any aetiology (liver biopsy or a combination of clinical and biochemical variables plus evidence of portal hypertension); without decompensation during the past month; serum creatinine \<1.5 mg/dL; able to attend the appointed visits and willing to participate in the study.

Exclusion Criteria

•Presence of high-risk varices in upper endoscopy (red marks, large varices or gastric varices); concomitant cardiopulmonary diseases; decompensated Type 2 Diabetes Mellitus, insulin use or proliferative diabetic retinopathy; orthopaedic or osteomuscular limitations; any type of cancer, primary sclerosing cholangitis and Inflammatory bowel disease.