Effects of Acute Pain on Cognitive Performance in Young Adults

University of Delaware1 site in 1 country23 target enrollmentMarch 22, 2023

ConditionsPain, Acute Cognition

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Pain, Acute
Sponsor: University of Delaware
Enrollment: 23
Locations: 1
Primary Endpoint: Digit Span Forward & Backward Test
Status: Completed
Last Updated: 2 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

The effects of pain on cognitive performance have not been thoroughly investigated. Broadly, the purpose of this research is to investigate the effects of acute pain on performance of a variety of cognitive performance measures. The investigators hypothesize that acute pain impairs cognitive performance, particularly cognitive measures of working memory, attention, and processing speed.

Registry

clinicaltrials.gov

Start Date

March 22, 2023

End Date

November 16, 2023

Last Updated

2 years ago

Study Type

Interventional

Study Design

Parallel

Sex

All

Investigators

Sponsor

University of Delaware

Responsible Party

Principal Investigator

Susanne M Morton

Associate Professor

University of Delaware

Eligibility Criteria

Inclusion Criteria

•18-35 years old
•Self-identifying as generally medically healthy
•Able to read, write and speak English
•Able to provide informed consent
•Willing to undergo the experimental pain or non-painful electrical stimulation, if selected

Exclusion Criteria

•Resting HR \< 50 or \> 100 bpm
•Resting BP \< 90/60 or \> 140/95 mmHg
•Any history or current mental health condition, learning/developmental disability or cognitive impairment, including ADD/ADHD, severe anxiety, severe depression, autism spectrum disorder, insomnia, mild cognitive impairment, etc.
•Score on the MoCA \<23
•Score on the GAD-7 ≥ 10
•Score on the PHQ-2 ≥ 2 and score on the PHQ-9 ≥ 10
•Any current (within last 3 month) or chronic medical conditions, including any musculoskeletal, cardiovascular, endocrine, pulmonary, metabolic, psychiatric or neurological diagnosis
•Any implanted electronic medical devices (i.e., cardiac pacemakers, cardiac defibrillators, spinal cord neurostimulators)
•Any impaired sensation or weakness in either lower extremity or in the area targeted for the stimulus
•History of serious concussion or head injury, defined as a loss of consciousness for \> 5 minutes and/or requiring medical treatment, or \> 2 concussions over the lifespan

Outcomes

Primary Outcomes

Digit Span Forward & Backward Test

Time Frame: the change between baseline and delivery (during application of intervention)

number of digits (numbers) that can be repeated back in the same (DS forward) or the reverse (DS backward( order from which they were presented

Trail Making Test A & B

Time Frame: the change between baseline and delivery (during application of intervention)

time required to draw a line connecting a series of numbers (TM-A) or a series of alternating letters and numbers (TM-B)

Secondary Outcomes

Hopkins Verbal Learning Test- Revised(the change between baseline and delivery (during application of intervention))
Brief Visuospatial Memory Test- Revised(the change between baseline and delivery (during application of intervention))
Conner's Continuous Performance Test (CPT) 3(the change between baseline and delivery (during application of intervention))
Stroop Test(the change between baseline and delivery (during application of intervention))
Wisconsin Card Sorting Test(the change between baseline and delivery (during application of intervention))
NIH Toolbox List Sorting(the change between baseline and delivery (during application of intervention))
NIH Toolbox Flanker(the change between baseline and delivery (during application of intervention))
Delis Kaplan Executive Functional System (D-KEFS) - Verbal Fluency Section(the change between baseline and delivery (during application of intervention))
NIH Toolbox Dimension Change Card Sort(the change between baseline and delivery (during application of intervention))
Wechsler 4th ed - Spatial Addition(the change between baseline and delivery (during application of intervention))
NIH Toolbox Picture Sequence(the change between baseline and delivery (during application of intervention))
NIH Toolbox Pattern Comparison(the change between baseline and during application of intervention)