Effect of Seashell Nanoparticles and Gluma Desensitizer on Sensitivity of Teeth Prepared for Intra Coronal Restorations as Well as Micromorphology of The Treated Dentin Surfaces
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 33
- 试验地点
- 1
- 主要终点
- Desnsetizing agent Hypersensitivity
研究概览
简要总结
Tooth hypersensitivity is characterized by a transient short and sharp pain originating from exposed dentin in response to thermal, dehydrating, tactile, osmotic, and chemical stimuli. Tooth sensitivity after cementation of complete coverage crowns, is a rather common event since much of the protecting enamel is removed during preparation and a large area of dentin is exposed.
Dentin contains up to two million tubules per cm2, which corresponds approximately to the surface area of most crown preparations. It is well known that such dentin wounds respond to mechanical, osmotic, or thermal stimulation with pain. This phenomenon is commonly example by the hydrodynamic theory of Brannstrom.
详细描述
The extent and duration of post cementation hypersensitivity has been related to number of factors, mainly associated with preparation trauma. However, research reports confirm potential effects of luting agents used and leakage of bacteria and bacterial products from the oral cavity along the margins of restorations, especially as a response to poorly fitting temporary restorations. Apparently, a relationship exists between the time interval during which the temporary restoration is in place and post cementation sensitivity.
Gluma Desensitizer is a combination of glutaraldehyde and HEMA (Hydroxy Ethyl Methacrylate). Glutaraldehyde causes amino acids and proteins to coagulate in dentinal tubules and is an effective disinfectant. HEMA can be effective in sealing of dentinal tubules.
Gluma does not interfere with dentin bonding systems but its glutaraldehyde component can damage the gingiva after long term exposure. HEMA can cause contact dermatitis and it can actually perforate latex gloves and must be used with caution, hence, the use of rubber dam is advised in such cases .
HEMA is soluble in water allowing it to penetrate deep into dentinal tubules however, the effect is reversible and HEMA gradually loses its effect allowing the dentinal tubules to again became exposed.
Hydroxyapatite powder is one such material that exhibits excellent bioactive properties and striking similarities to dental hard tissues can be achieved from two different sources. Synthetic and natural (biologic) hydroxyapatite.HAP can be produced from Coral Seashells, eggshells and also from body fluids.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 25 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •For patient Age between 25 and 40 years and no gender reference.
- •For the teeth Absence of pulpal exposure, RCT treatments, fracture and free of extensive caries (The amount of caries that can be removed during the preparation is acceptable
排除标准
- •-For patients Use of desensitizing substances or drug like antihistamines, antidepressant 6 weeks before or during the study.
- •Requiring antibiotic prophylaxes or cortico-steriod therapy.
- •For teeth Tooth hypersensitivity prior to tooth preparation (like, abrasion or attration).
结局指标
主要结局
Desnsetizing agent Hypersensitivity
时间窗: from 0 hours to two weeks
Evaluation of the treated patients from hypersensitivity of the application of desnsetizing agent ( gluma and nanasaesheall) by using VAS score (from 0 to 10) as 0 is mean no sensitivity while 10 is the worst.
次要结局
- Dentinal tubule occlusion(from 0 hours to two weeks)
研究者
Hoda Fathy El gendy
Specialist of Dental Medicine
Faculty of Dental Medicine for Girls