Predictive Value of Serum Uric Acid to High Density Lipoprotein Cholesterol Ratio for Diabetic Kidney Injury in Type 2 Diabetes
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 100
- 主要终点
- Uric acid to HDL-c ratio (UHR)
研究概览
简要总结
An prospective observetional study to asses the predictive value of serum uric acid to high density lipoprotein cholesterol ratio for diabetic kidney injury in type 2 diabetes
详细描述
Diabetic Kidney Injury (DKI) is a serious microvascular complication of diabetes mellitus occuring in about 20 % to 50% of diabetic patients and is the single commonest cause of ESRD.DKI is asociated with arterial HTN and increased cardiovascular morbidity and mortality. outcomes for both type 1 DM and type 2 DM who develop DKI are significantly worse than who do not .Serum uric acid was reported to be asociated with inflamatory and metabolic diseases such as metabolic syndrome , type 2 DM,thyroiditis and NAFLD while HDL-cholesterol decreased the odds of developing DKI by 20%.It is generally accepted that hyperuricemia and low HDL-c were considered to be a risk factor of other indicators for development of DKI.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Crossover
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Type 2 diabetic patients
- •willing and agreed to be included in the study
排除标准
- •Type 1 DM patients
- •patients with active urinary sediment
- •patients with glomerulonephritis
- •patients with diagnosis or clinical features that are suspicious for another systemic disease that commonly causes kidney disease
- •patients with evidence of alternative kidney disease
- •patients with history of kidney transplantation
- •patients with end stage renal disease
- •patients with family history of non diabetic forms of kidney disease
- •patients with active malignancy
- •patients with established hemolytic disease
- •CKD patients requiring dialysis
- •patients taking drugs that interfere with serum uric acid level
- •patients taking drugs that alter serum lipids level
- •pregnancy
- •Refused to consent to this study
结局指标
主要结局
Uric acid to HDL-c ratio (UHR)
时间窗: 6 months
asociation of high UHR with development of DKI in type 2 DM
次要结局
未报告次要终点
研究者
Eldeeb Elsayed Mohamed
Eldeeb Elsayed Mohamed
Sohag University