Predictive Value of Serum Uric Acid to HDL Cholesterol Ratio for Diabetic Kidney Injury in Type 2 Diabetes
- Conditions
- Diabetic Kidney Injury
- Interventions
- Diagnostic Test: serum uric acid level to plasma HDL-c level ratio (UHR)
- Registration Number
- NCT06349850
- Lead Sponsor
- Sohag University
- Brief Summary
An prospective observetional study to asses the predictive value of serum uric acid to high density lipoprotein cholesterol ratio for diabetic kidney injury in type 2 diabetes
- Detailed Description
Diabetic Kidney Injury (DKI) is a serious microvascular complication of diabetes mellitus occuring in about 20 % to 50% of diabetic patients and is the single commonest cause of ESRD.DKI is asociated with arterial HTN and increased cardiovascular morbidity and mortality. outcomes for both type 1 DM and type 2 DM who develop DKI are significantly worse than who do not .Serum uric acid was reported to be asociated with inflamatory and metabolic diseases such as metabolic syndrome , type 2 DM,thyroiditis and NAFLD while HDL-cholesterol decreased the odds of developing DKI by 20%.It is generally accepted that hyperuricemia and low HDL-c were considered to be a risk factor of other indicators for development of DKI.
Recruitment & Eligibility
- Status
- NOT_YET_RECRUITING
- Sex
- All
- Target Recruitment
- 100
- Type 2 diabetic patients
- willing and agreed to be included in the study
- Type 1 DM patients
- patients with active urinary sediment
- patients with glomerulonephritis
- patients with diagnosis or clinical features that are suspicious for another systemic disease that commonly causes kidney disease
- patients with evidence of alternative kidney disease
- patients with history of kidney transplantation
- patients with end stage renal disease
- patients with family history of non diabetic forms of kidney disease
- patients with active malignancy
- patients with established hemolytic disease
- CKD patients requiring dialysis
- patients taking drugs that interfere with serum uric acid level
- patients taking drugs that alter serum lipids level
- pregnancy
- Refused to consent to this study
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description UHR level group serum uric acid level to plasma HDL-c level ratio (UHR) median levels of UHR will be used to dichotomize the patients into groups of : * low UHR group * high UHR group DKI group serum uric acid level to plasma HDL-c level ratio (UHR) study population will be grouped into another two groups according to the presence of DKI: * patients with DKI * patients without DKI HbA1c level group serum uric acid level to plasma HDL-c level ratio (UHR) * well controlled diabetic group : HBA1c less than 7% * poorly controlled diabetic group : HBA1c equal to ore more than 7%
- Primary Outcome Measures
Name Time Method Uric acid to HDL-c ratio (UHR) 6 months asociation of high UHR with development of DKI in type 2 DM
- Secondary Outcome Measures
Name Time Method