The Correlation Between Oxidative Stress and Indinated Contrast-Media Nephrotoxicity
Completed
- Conditions
- Kidney Diseases
- Registration Number
- NCT00632892
- Lead Sponsor
- Far Eastern Memorial Hospital
- Brief Summary
Clinically, iodinated contrast-medium (CM) is widely used in angiography and computerized tomography. CM-induced nephropathy (CMIN) is one major complication after application of CM. Therefore, how to prevent CMIN is always one of the hot topics concerned by nephrologists, cardiologists, and radiologists.
The present study is aimed to determine the norepinephrine concentration, oxidative markers, and tubular damage markers in the urine samples of patients undergoing intravenous pyelography (IVP).
The working hypothesis is high-osmolarity contrast media (HOCM) causes more oxidative stress and greater tubular damage than iso-osmolarity contrast media (IOCM).
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 80
Inclusion Criteria
- Adult patients (> 18 years old)
- Undergoing IVP with an appropriate medical indication
- Signing informed consent
Exclusion Criteria
- Without signing informed consent
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Far Eastern Memorial Hospital
🇨🇳Pan Chiao, Taipei, Taiwan