The Correlation Between Oxidative Stress and Indinated Contrast-Media Nephrotoxicity

Far Eastern Memorial Hospital1 个研究点分布在 1 个国家目标入组 80 人开始时间: 2007年12月最近更新: 2008年3月11日

适应症

试验速览

阶段: 不适用
状态: 已完成
发起方: Far Eastern Memorial Hospital
入组人数: 80
试验地点: 1

研究概览研究设计入排标准研究者研究点记录与标识符相似试验

研究概览

简要总结

Clinically, iodinated contrast-medium (CM) is widely used in angiography and computerized tomography. CM-induced nephropathy (CMIN) is one major complication after application of CM. Therefore, how to prevent CMIN is always one of the hot topics concerned by nephrologists, cardiologists, and radiologists.

The present study is aimed to determine the norepinephrine concentration, oxidative markers, and tubular damage markers in the urine samples of patients undergoing intravenous pyelography (IVP).

The working hypothesis is high-osmolarity contrast media (HOCM) causes more oxidative stress and greater tubular damage than iso-osmolarity contrast media (IOCM).

研究设计

研究类型: Observational
观察模型: Case Only
时间视角: Prospective

入排标准

年龄范围: 18 Years 至 —（Adult, Older Adult）
性别: All
接受健康志愿者: 否

入选标准

•Adult patients (> 18 years old)
•Undergoing IVP with an appropriate medical indication
•Signing informed consent

排除标准

•Without signing informed consent

研究者

发起方

Far Eastern Memorial Hospital

申办方类型

Other

研究点 (1)

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