Effect of isoflurane on diastolic dysfunctio

Not Applicable

Recruiting

• Conditions: Surgery; Ischemic heart disease with diastolic dysfunction.

• Registration Number: PACTR201701001983201
• Lead Sponsor: Fayoum University hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2017-01-18
• Last Update Posted: 29 May 2023

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 54

Inclusion Criteria

Non-emergent coronary artery bypass grafting surgery.
Left ventricular ejection fraction of 45% or more.
Grade 1 diastolic dysfunction.

Exclusion Criteria

Cardiac valvular pathology.
Myocardial infarction within 4 weeks.
Body mass index greater than 40 kg/m2.
Pacemaker therapy.
Left bundle branch block or Atrial fibrillation.
Esophagitis or esophageal varices.
Hypertrophic obstructive cardiomyopathy or infiltrative myocardial disease.
Emergency CABG and patients coming on inotropes or mechanical ventilation.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Trans mitral flow velocity profile measured by by pulsed wave Doppler (PWD).

Secondary Outcome Measures

Name	Time	Method
Pulmonary vein flow velocity profile measured by PWD.;Tissue Doppler imaging of the mitral annulus.;Hear rate;Mean arterial pressure;central venous pressure