EUCTR2023-000172-36-BE招募中1 期
Intraoperative methadone for the prevention of postoperative pain: a randomized, double-blind clinical study in orthopedic surgery.
相关药物
试验速览
- 阶段
- 1 期
- 状态
- 招募中
- 发起方
- CHU Brugmann
- 入组人数
- 80
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- All
入选标准
- •Age between 18 and 80 years old
- •ASA 1-3 status
- •Elective partial or total hip and knee arthroplasty
- •Are the trial subjects under 18? no
- •Number of subjects for this age range:
- •F.1.2 Adults (18-64 years) yes
- •F.1.2.1 Number of subjects for this age range 55
- •F.1.3 Elderly (>=65 years) yes
- •F.1.3.1 Number of subjects for this age range 25
排除标准
- •Patient refusal
- •Preoperative renal failure (serum creatinine > 2 mg/dL or 1.5-fold increase in basal plasma creatinine or GFR < 50 ml/min/1.73m2)
- •Significant hepatic dysfunction (PT <50% or increase in 3 times basal transaminases)
- •Known heart failure
- •Preoperative hemodynamic instability (preoperative use of inotropes or vasopressors)
- •Known methadone or sufentanil allergy
- •Preoperative opioid use or history of opioid abuse
- •Pregnancy and breastfeeding
- •Treatment with beta blockers and HR < 60 bpm
- •Treatment with antidepressants
研究者
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