Use of Injectable-platelet-rich-fibrin (I-PRF) to Thicken Gingival Phenotype

Not Applicable

Completed

• Conditions: Blood Clot; Periodontoclasia; Condition; Gingiva Disorder; Gingiva; Injury
• Interventions: Other: I-PRF

• Registration Number: NCT03274674
• Lead Sponsor: Bezmialem Vakif University

Brief Summary

The main objective of this study is to investigate whether the for individuals with thin gingival thickness who are susceptible to gingival recession, the investigators will use i-PRF with microneedle to increase gingival thickness without the need for surgical procedures

Detailed Description

Due to the thin gingival phenotype, gingival recession is a problem. The investigators aimed to increase the gingival thickness using i-PRF with microneedle without considering surgical procedures, considering the positive effects of platelet concentrations on revascularization and wound healing in individuals with bone defect, fenestration and gingival thickness which are prone to gingival recession .

Study Timeline

• Study Start: 2017-04-04
• Study First Submitted: 2017-09-05
• Study First Submitted QC: 2017-09-05
• Study First Posted: 2017-09-07
• Primary Completion: 2018-01-01
• Study Completion: 2018-06-01
• Status Verified: 2020-09
• Last Update Submitted: 2020-09-08
• Last Update Posted: 2020-09-09

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 29

Inclusion Criteria

• Never smokers
• Had no history of systemic disease
• Aged ≥18 years old

Exclusion Criteria

• Patients with a history of diabetes mellitus or systemic disease
• Patients who were under any medication that was known to influence periodontal tissues
• Patients with hormonal changes such as pregnancy or lactation
• Toothless individuals
• Patients who were clotting disorders

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
I-PRF	I-PRF	Venous blood will be taken from the patient every session and I-PRF will be created in the centrifuge.I-PRF injected on one side of bilateral thin gingival thickness.Apply once a week and one month after the end of the injections, the patient will be called to the control.
I-PRF and Microneedling	I-PRF	Venous blood will be taken from the patient every session and I-PRF will be created in the centrifuge.Microneedle application plus I-PRF injected on the other side in patients with bilateral region with thin gingival phenotype.Apply once a week and one month after the end of the injections, the patient will be called to the control.

Primary Outcome Measures

Name	Time	Method
Gingival thickness (mm)	2 months	Change in clinical measures of gingival thickness

Secondary Outcome Measures

Name	Time	Method
Plaque Index (PI)	2 months	Change in clinical measures of gingival parameters
Bleeding on probing (BOP)	2 months	Change in clinical measures of gingival parameters
Gingival Index (GI)	2 months	Change in clinical measures of gingival parameters
Clinical attachment level (CAL)	2 months	Change in clinical measures of gingival parameters
Probing pocket depth (PD)	2 months	Change in clinical measures of gingival parameters

Trial Locations

Locations (1)

Zeliha Betül ÖZSAĞIR; 🇹🇷 İstanbul, Turkey