The Effects of Autologous Platelet-Rich Plasma Cream on Photoaging and Chronological Skin Aging
试验速览
- 阶段
- 1 期
- 发起方
- 入组人数
- 20
- 试验地点
- 4
- 主要终点
- Global efficacy evaluations and quantitative analyzes.
研究概览
简要总结
Human skin undergoes some morphological changes with the effects of chronological aging and photoaging, these are especially remarkable in the facial skin. Changes in pigmentation, sallowness, deep wrinkling, laxity and elastosis are the main changes seen in photoaging and chronologic aging of skin. With the increasing demand, it needs to provide new approach for the prevention and treatment of these morphological changes.
Fibroblasts have a key role on skin aging. It is known that platelet rich plasma activates the fibroblasts and increases the synthesis of collagen and other type of matrix components. Because of these specialities, platelet rich plasma is thought to be effective on skin aging.
详细描述
Clinical evaluation of the patients will be done for five times during 3 months. 0th day (Basal), 7th day, 15th day, 45th day and 105th day.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- Double (Participant, Care Provider)
入排标准
- 年龄范围
- 35 Years 至 65 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •The patient has periorbital wrinkles with Glogau Scale 3 or more
排除标准
- •Patients with precancerous lesions
- •Patients with inflammatory skin disease like rosacea, psoriasis, seborrheic eczema
- •Patients with connective tissue disease like lupus erythematosus
- •Patients have a cosmetic intervention to their face, like chemical peel, infrared, radio frequency, laser, fillers or botulinum toxin injections in last 6 months
- •Patients who use an anti aging cream containing retinoic acid, vitamin C and peptides in last 3 months
- •Pregnant or lactating females
结局指标
主要结局
Global efficacy evaluations and quantitative analyzes.
时间窗: T4 (105th day)
Evaluation of deep and fine wrinkling, amount of pigmentation, amount of vascularization, clarity of skin assessment done by the patient and the investigator. Quantitative analyzes: Measurements of Antera and Cutometer.
次要结局
- Number of Participants with Adverse Events and Type of Adverse Effects.(T1 (7th day), T2 (15th day), T3 (45th day,) T4 (105th day))
- Deep and fine wrinkling,(T0 (basal condition),T1 (7th day), T2 (15th day), T3 (45th day,) T4 (105th day))
- Amount of vascularization(T0 (basal condition),T1 (7th day), T2 (15th day), T3 (45th day,) T4 (105th day))
- Clarity of skin(T0 (basal condition),T1 (7th day), T2 (15th day), T3 (45th day,) T4 (105th day))
- Smell and texture of cream(T4 (105th day))
- Changes from baseline and placebo group.(T0 (basal condition),T1 (7th day), T2 (15th day), T3 (45th day,) T4 (105th day))
- Amount of pigmentation(T0 (basal condition),T1 (7th day), T2 (15th day), T3 (45th day,) T4 (105th day))
研究者
Ercument Ovali
Specialist, Haematology
Acibadem University