Ultrafast Ultrasonographic Oro-laryngeal Measurement in Critically Ill Patients During Weaning From Mechanical Ventilation
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 150
- 试验地点
- 1
- 主要终点
- Correlation between laryngeal ultrafast ultrasonography and occurence of laryngeal edema
研究概览
简要总结
In ICU, ventilatory weaning failure is common, accounting for up to 25% of extubations. These failures are largely due to swallowing disorders and laryngeal edema. Edema prevalence in ICU varies between 4 and 37%.
Post-extubation stridor is a clinical sign of upper airway obstruction and may require urgent reintubation, which is associated with increased patient length of stay, morbidity and mortality.
Identifying patients at risk is critical, and the need for reliable tools to predict the occurence of laryngeal edema is still relevant.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Intubated and ventilated for more than 24h,
- •Filing mechanical ventilation weaning criteria.
排除标准
- •Pregnant of breast-feeding woman,
- •Under guardianship patient,
- •History of laryngeal tumor, stroke, paralysis of recurrent nerve, swallowing disorders,
- •History of surgical laryngeal intervention or radiotherapy,
- •Unplanned extubation,
- •Opposition to take part in the study.
结局指标
主要结局
Correlation between laryngeal ultrafast ultrasonography and occurence of laryngeal edema
时间窗: Within the 24 hours following extubation
A laryngeal edema is defined as a post-extubation stridor. Performance of ultrafast ultrasonography for laryngeal edema prediction in intensive care patients will be assessed with specificity, sensitivity, positive predictive value and negative predictive value.
次要结局
- Correlation between laryngeal ultrafast ultrasonography and occurence of swallowing disorders(Within the 24 hours following extubation)