Performance Evaluation of Real-time Fluorescence-guided Resection of Peritoneal Metastases in Ovarian Cancer USing IndoCyanine Green during Interval Cytoreductive Surgery (FOCUS-ICG)

This study aims to evaluate the performance of ICG-guided near-infrared fluorescence imaging in enhancing intraoperative detection of occult peritoneal metastases during interval cytoreduction surgery in ovarian cancer. Primary objective is to evaluate the detection rate of additional peritoneal nodules with near-infrared fluorescence imaging with indocyanine green in identifying occult peritoneal metastases during interval cytoreductive surgery in patients with ovarian cancer. Female patients aged more than 18 years with histolopathologically confirmed ovarian cancer, FIGO stage III or IV and completed more than or equal to 3 cycles of platinum-based neoadjuvant chemotherapy and scheduled for an interval cytoreductive surgery, ECOG performance status 0 to 2 and provided written informed consent will be included. This study addresses a critical gap by evaluating the real-time utility of ICG NIRF imaging in enhancing intraoperative identification of otherwise occult disease. By focusing on its performance in the post-chemotherapy setting, our work aims to clarify whether this technology can support more complete cytoreduction, guide surgical decision making, and ultimately contribute to improved outcomes for women with advanced ovarian cancer