The Acute Effects of Oleic Acid Enriched-diets on Lipids, Insulin Sensitivity and Serum Inflammatory Markers
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 10
- 试验地点
- 2
- 主要终点
- Triacylglycerol (TAG)
研究概览
简要总结
Objectives: To investigate the acute effects of olive oil, palm olein and lard on lipid profile, insulin sensitivity and inflammatory markers.
Hypothesis: Different dietary fats will alter lipid profile, insulin sensitivity and inflammatory markers postprandially.
详细描述
A randomized, single blind, crossover design was undertaken to test meals enriched with palm olein vs olive oil vs lard. Volunteers were asked to participate in three postprandial challenges, separated by at least 3-days. Subjects were provided a low fat meal(<10g fat) the day before the intervention. Fasting blood was collected the next day and the subjects were instructed to consume test meals (50g high fat meal). Further venous blood was collected at 30 min, 1h, 2h, 3h and 4h postprandially.
Primary outcome variable: Triacylglycerol (TAG) Secondary outcome variables: Insulin sensitivity (glucose, insulin), non esterified fatty acids (NEFA), inflammatory markers
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Prevention
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Age: 18-45 years
- •BMI : 18.5-30 kg/m^2
- •Healthy, men
排除标准
- •medical history of cardiovascular disease, cancer, diabetes or chronic diseases
- •BMI < 18.5 OR > 30 kg/m^2
- •waist hip ratio > 0.9
- •total cholesterol > 5.2 mmol/L
- •triacylglycerol (TAG) > 2.2 mmol/L
- •current use of antihypertensive or lipid lowering medication
结局指标
主要结局
Triacylglycerol (TAG)
时间窗: 4 h
次要结局
- Insulin sensitivity (glucose, insulin), non-esterified fatty acids (NEFA), inflammatory markers(4 h)