Assessing the utility of Androgen Receptor (AR) expression as a histopathological marker for tumor behavior in comparison to histopathological parameters and Tumor, Nodes and Metastasis staging in colorectal carcinoma.
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- The study is expected to determine the significance of androgen receptor expression in colorectal carcinoma by correlating it with tumor behavior, histopathological grade, and TNM staging.
研究概览
简要总结
This prospective and retrospective observational study will be conducted in the Histopathology and Immunohistochemistry sections of the Department of Pathology, Jawaharlal Nehru Medical College, in collaboration with the Department of General Surgery at Acharya Vinoba Bhave Rural Hospital. It will aim to evaluate androgen receptor (AR) expression in colorectal carcinoma using immunohistochemistry and will correlate the findings with histopathological grade and TNM staging. As the incidence of colorectal cancer in India is expected to continue rising, particularly among younger individuals, and with limited research on hormonal influences such as AR, this study will seek to clarify AR’s role in tumor progression and prognosis. The outcomes will help identify high-risk subtypes and may guide the development of hormone-based therapeutic strategies tailored to the Indian population.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18.00 Year(s) 至 99.00 Year(s)（—）
- 性别
- All
入选标准
- •Already diagnosed as Colorectal carcinoma on histopathology.
- •All operated cases of colectomy/ hemicolectomy/ abdominoperineal resection with suitable lymph node dissection.
- •Primary cases of Colorectal carcinoma without any history of previous treatment.
- •All patients with Colorectal carcinoma arising de novo.
排除标准
- •All benign lesions of colon and rectum and other malignant carcinomas like neuroendocrine tumors and gastrointestinal stromal tumor.
- •All the already treated cases of Colorectal Carcinoma.
- •All patients with Colorectal carcinoma where the cancer is arising as a result of recurrence.
- •Patients with no histological confirmation of Colorectal Carcinoma.
- •All patients who have defaulted treatment.
结局指标
主要结局
The study is expected to determine the significance of androgen receptor expression in colorectal carcinoma by correlating it with tumor behavior, histopathological grade, and TNM staging.
时间窗: 2 years
次要结局
未报告次要终点
研究者
Dr Prakritee Sandilya
Jawaharlal Nehru Medical College, Wardha