Calcium Supplementation to Prevent Preeclampsia in Sichuan Province of China

Not Applicable

• Conditions: Preeclampsia
• Interventions: Drug: calcium

• Registration Number: NCT01806454
• Lead Sponsor: West China Second University Hospital

Brief Summary

the purpose of this study is to determine whether calcium supplementation is effective to prevent preeclampsia in Sichuang Province of china and which dose is more suitable

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2013-03-01
• Study First Submitted QC: 2013-03-06
• Study First Posted: 2013-03-07
• Study Start: 2013-10
• Status Verified: 2014-04
• Last Update Submitted: 2015-08-24
• Last Update Posted: 2015-08-25
• Primary Completion: 2015-11

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: Female
• Target Recruitment: 11000

Inclusion Criteria

• Nulliparity;age ≥35 years;Previous pre-eclampsia;Family history of pre-eclampsia;Multiple pregnancy;Time between pregnancies ≥10years;Body mass index ≥25;diastolic pressure ≥ 80 mm Hg before 20 weeks' gestation;Proteinuria ≥+ on more than one occasion or ≥ 300 mg/24 h before 20 weeks' gestation;Underlying medical conditions(Pre-existing hypertension;Pre-existing renal disease;Pre-existing diabetes;Presence of antiphospholipid antibodies;Chronic autoimmune disease);male sex partner's predecessor wife has Previous pre-eclampsia

Exclusion Criteria

• first prenatal visit after 16 weeks' gestation;severe anemia;other Underlying medical conditions which need treatment first (such as uncontrolled hyperthyreosis )

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
calcium A	calcium	tablets, 600mg per day,till birth
calcium B	calcium	tablets,1200mg per day,till birth

Primary Outcome Measures

Name	Time	Method
incidence of pre-eclampsia	postpartum forty-two days