NCT01806454Unknown不适用
Calcium Supplementation to Prevent Preeclampsia in Sichuan Province of China: a Multi-center, Prospective Random Trial
West China Second University Hospital0 个研究点目标入组 11,000 人开始时间: 2013年10月最近更新:
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 11,000
- 主要终点
- incidence of pre-eclampsia
研究概览
简要总结
the purpose of this study is to determine whether calcium supplementation is effective to prevent preeclampsia in Sichuang Province of china and which dose is more suitable
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Nulliparity;age ≥35 years;Previous pre-eclampsia;Family history of pre-eclampsia;Multiple pregnancy;Time between pregnancies ≥10years;Body mass index ≥25;diastolic pressure ≥ 80 mm Hg before 20 weeks' gestation;Proteinuria ≥+ on more than one occasion or ≥ 300 mg/24 h before 20 weeks' gestation;Underlying medical conditions(Pre-existing hypertension;Pre-existing renal disease;Pre-existing diabetes;Presence of antiphospholipid antibodies;Chronic autoimmune disease);male sex partner's predecessor wife has Previous pre-eclampsia
排除标准
- •first prenatal visit after 16 weeks' gestation;severe anemia;other Underlying medical conditions which need treatment first (such as uncontrolled hyperthyreosis )
研究组 & 干预措施
calcium A
Active Comparator
tablets, 600mg per day,till birth
干预措施: calcium (Drug)
calcium B
Active Comparator
tablets,1200mg per day,till birth
干预措施: calcium (Drug)
结局指标
主要结局
incidence of pre-eclampsia
时间窗: postpartum forty-two days
次要结局
未报告次要终点
研究者
Xinghui Liu
Professor
West China Second University Hospital
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