Specific Molecular Imaging of DX600 Labeled by PET Radionuclide Targeting ACE2 in Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- SUV
研究概览
简要总结
Angiotensin-converting enzyme 2 (ACE2) plays an important role in renin-angiotensin system (RAS) and has been reported to relate with cancer. Recently, it has also been proved as the key target for COVID-19 infection.
DX600 is a polypeptide that can specific binding to ACE2 specifically with nanomolar affinity reported in literature. This study constrcuted a radio-tracer, DX600 Labeled by PET Radionuclide, to monitoring biodistribution ACE2 in human beings, evaluate the detection ability of radio-tracer in ACE2 over-expression tumors and dynamic changes of ACE2 expression under therapy.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age 18-75 years old; both sex;
- •ECoG 0 or 1;
- •Patients that would undergo biopsy or surgical operation with high ACE2 expression tumors such as colorectal cancer, renal cancer, pancreatic cancer, gastric cancer, liver cancer, lung cancer, brain cancer or suspected tumor.
- •use 18F-FDG PET/CT as baseline evaluation
排除标准
- •Significant hepatic or renal dysfunction;
- •Is Pregnant or ready to pregnant;
- •Cannot lie on their back for half an hour;
- •Suffering from claustrophobia or other mental diseases;
- •Refusal to join the clinical study;
结局指标
主要结局
SUV
时间窗: 2 years
The uptake of uptake of the tracer in the primary and metastatic tumor lesions by measuring standardized uptake value（SUV）
次要结局
未报告次要终点
研究者
Hua Zhu
Associate Professor
Peking University Cancer Hospital & Institute