To study the efficacy of using a combination of a topical Triple combination cream with Fractional CO2 laser in the treatment of facial melasma compared to Triple combination cream alone
Phase 2
- Conditions
- Health Condition 1: L811- Chloasma
- Registration Number
- CTRI/2019/04/018702
- Lead Sponsor
- All India institute of medical sciences New Delhi
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
a. Patients with clinical diagnosis ofbilateral melasma
b. More than 18 years of age of either sex
c. Patients not on any topical or systemic treatment for melasma in the last 4 weeks.
Exclusion Criteria
a. Pregnant or lactating females
b. Patients on oral contraceptives, hormone replacement therapy in the last three months
c. Patients with any significant disease of gastrointestinal, hepatic, renal, pulmonary, hematological or endocrine system.
d. Patients with photosensitive disorders like lupus erythematosus, porphyria, etc.
e. History of known hypersensitivity to the interventional agents used in the study like fractional lasers, topical hydroquinone, retinoic acid and corticosteroids.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method ASSESSMENT PARAMETERS <br/ ><br> <br/ ><br>Physicians global assessment scale <br/ ><br>Patients global assessment scale <br/ ><br>Photographic assessment by physician <br/ ><br>Change in modified MASI score from baseline <br/ ><br>Change in melanin index from baselineTimepoint: ASSESSMENT PARAMETERS <br/ ><br> <br/ ><br>Parameters will be assessed every monthly for a total duration of 6 months
- Secondary Outcome Measures
Name Time Method ATimepoint: NA