Effect of Pexelizumab on All-Cause Mortality and Myocardial Infarction in Patients Undergoing Coronary Artery Bypass Graft Surgery With Cardio-Pulmonary Bypass
- Conditions
- Cardio-pulmonary BypassCoronary Artery Bypass Graft
- Registration Number
- NCT00048308
- Lead Sponsor
- Alexion Pharmaceuticals, Inc.
- Brief Summary
During a heart bypass procedure, a substance called "complement" is released by the body. This complement causes inflammation, which can lead to side effects such as chest pain, heart attacks, heart failure, or impairment of memory, language and motor skills. The purpose of this study is to find out if the study drug (pexelizumab), which blocks complement release, can reduce such side effects and be taken safely.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 3000
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (180)
Northside Hospital ans Heart Institute
🇺🇸St. Petersburg, Florida, United States
University of Illinois - Chicago
🇺🇸Chicago, Illinois, United States
Sparks Regional Medical Center
🇺🇸Fort Smith, Arkansas, United States
Emory University Hospital
🇺🇸Atlanta, Georgia, United States
Cardiovascular Associates of the Delaware Valley
🇺🇸Haddon Heights, New Jersey, United States
Westchester County Medical Center
🇺🇸Valhalla, New York, United States
The Chattanooga Heart Institute Cardiovascular Group, P.C.
🇺🇸Chattanooga, Tennessee, United States
University of Texas Southwestern Medical Center
🇺🇸Dallas, Texas, United States
Camcare Health Education & Research Institute
🇺🇸Charleston, West Virginia, United States
Victoria Heart Institute
🇨🇦Victoria, British Columbia, Canada
University Hopital of Cleveland
🇺🇸Cleveland, Ohio, United States
Community Hospital
🇺🇸Indianapolis, Indiana, United States
Good Samaritan Hospital
🇺🇸Cincinnati, Ohio, United States
Sterling Research Group
🇺🇸Cincinnati, Ohio, United States
Good Samaritan Hospital -Seton Center
🇺🇸Cincinnati, Ohio, United States
Tri Health Bethesda North Hospital
🇺🇸Cincinnati, Ohio, United States
IMC-Diagnostic and Medical Clinic
🇺🇸Mobile, Alabama, United States
Saguaro Clinical Research
🇺🇸Tucson, Arizona, United States
Desert Samaritan - Lutheran Heart
🇺🇸Mesa, Arizona, United States
Southern Arizona VAMC
🇺🇸Tucson, Arizona, United States
Brotman Medical Center
🇺🇸Beverly Hills, California, United States
Cardiovascular Associates of the Peninsula
🇺🇸Burlingame, California, United States
Apex Cardiology
🇺🇸Inglewood, California, United States
St. Jude Medical Center
🇺🇸Fullerton, California, United States
University of Southern California
🇺🇸Los Angeles, California, United States
University of California - Los Angeles
🇺🇸Los Angeles, California, United States
St. Vincent's Hospital
🇺🇸Los Angeles, California, United States
Crozer-Chester Medical Center
🇺🇸Oakland, California, United States
Tri-City Medical Center
🇺🇸Oceanside, California, United States
Western Cardiology Associates
🇺🇸Denver, Colorado, United States
Heart and Vascular Clinic of Northern CO
🇺🇸Fort Collins, Colorado, United States
Bridgeport Hospital
🇺🇸Bridgeport, Connecticut, United States
Christiana Care Health Services
🇺🇸Newark, Delaware, United States
Cardiology Associates
🇺🇸Washington, District of Columbia, United States
Morton Plan Mease Health Care
🇺🇸Clearwater, Florida, United States
Florida Cardiovascular Research
🇺🇸Atlantis, Florida, United States
Heart Group Research
🇺🇸Fort Lauderdale, Florida, United States
Gulf Bay Cardiovascular and Thoracic Associates
🇺🇸Hudson, Florida, United States
MIMA Century Research Associates
🇺🇸Melbourne, Florida, United States
Medical Research Unlimited
🇺🇸Miami, Florida, United States
Jacksonville Center for Clinical Research
🇺🇸Jacksonville, Florida, United States
Brevard Cardiology Group, PA
🇺🇸Merritt Island, Florida, United States
Ford Research Center
🇺🇸Pensacola, Florida, United States
Cardiology Consultants
🇺🇸Pensacola, Florida, United States
Sarasota Memorial Hospital
🇺🇸Sarasota, Florida, United States
Tallahassee Memorial Regional Medical Center
🇺🇸Tallahassee, Florida, United States
VA Medical Center- Atlanta
🇺🇸Decatur, Georgia, United States
University Hospital
🇺🇸Augusta, Georgia, United States
St. Joseph's Hospital
🇺🇸Towson, Maryland, United States
VA Medical Center - Dubin
🇺🇸Macon, Georgia, United States
Northwestern Univ. Medical Center
🇺🇸Chicago, Illinois, United States
Evanston Northwestern Healthcare Evanston Hospital
🇺🇸Evanston, Illinois, United States
Indiana Ohio Heart
🇺🇸Fort Wayne, Indiana, United States
University of Iowa
🇺🇸Iowa City, Iowa, United States
University of Kansas City Medical Center
🇺🇸Kansas City, Kansas, United States
Wesley Medical Center
🇺🇸Wichita, Kansas, United States
Cardiovascular Institute of the South
🇺🇸Thibodaux, Louisiana, United States
Methodist Hospital
🇺🇸Houston, Texas, United States
Cardiac Centers of Louisiana
🇺🇸Shreveport, Louisiana, United States
Union Memorial Hospital
🇺🇸Baltimore, Maryland, United States
Midatlantic Cardiovascular Associates
🇺🇸Towson, Maryland, United States
Massachusetts General Hospital
🇺🇸Boston, Massachusetts, United States
Brigham and Womens Hospital
🇺🇸Boston, Massachusetts, United States
University of Massachusetts
🇺🇸Worcester, Massachusetts, United States
McLaren Regional Medical Center
🇺🇸Flint, Michigan, United States
West Shore Cardiology Research Department
🇺🇸Muskegon, Michigan, United States
Thoracic and Cardiovascular Institute
🇺🇸Lansing, Michigan, United States
Covenant Medical Center
🇺🇸Saginaw, Michigan, United States
William Beaumont Hospital
🇺🇸Royal Oak, Michigan, United States
St. Mary's Duluth Health System
🇺🇸Duluth, Minnesota, United States
St. Luke's Hospital-Duluth
🇺🇸Duluth, Minnesota, United States
North Memorial Hospital
🇺🇸Robbinsdale, Minnesota, United States
Park Nicollet Health Research Center
🇺🇸St. Louis Park, Minnesota, United States
Mississippi Center for Clinical Research
🇺🇸Jackson, Mississippi, United States
Christian North East Hospital
🇺🇸St. Louis, Missouri, United States
Cardiology diagnostics, Ltd.
🇺🇸St. Peters, Missouri, United States
United Health Services
🇺🇸Johnson City, New York, United States
Garden State Cardiology
🇺🇸Paramus, New Jersey, United States
Rochester General Hospital
🇺🇸Rochester, New York, United States
Asheville Cardiothoracic Surgeons
🇺🇸Asheville, North Carolina, United States
Akron General Medical Center
🇺🇸Akron, Ohio, United States
Summa Health Systems
🇺🇸Akron, Ohio, United States
Mt. Carmel West
🇺🇸Columbus, Ohio, United States
Bend Memorial Clinic
🇺🇸Bend, Oregon, United States
The Heart Center
🇺🇸Doylestown, Pennsylvania, United States
Allegheny General Hospital
🇺🇸Pittsburgh, Pennsylvania, United States
North Memorial Pain Institute
🇺🇸Philadelphia, Pennsylvania, United States
University of Pittsburgh Medical Center
🇺🇸Pittsburgh, Pennsylvania, United States
Guthrie Clinical Research
🇺🇸Sayre, Pennsylvania, United States
Chester County Cardiovascular Center
🇺🇸West Chester, Pennsylvania, United States
Baptist Memorial Hospital
🇺🇸Memphis, Tennessee, United States
Parkway Cardiovascular Associates
🇺🇸Oak Ridge, Tennessee, United States
VA Medical Center - Houston
🇺🇸Houston, Texas, United States
Texas Heart Institute
🇺🇸Houston, Texas, United States
Texas Tech University Health Center
🇺🇸Lubbock, Texas, United States
Scott and White Memorial Hospital
🇺🇸Temple, Texas, United States
Inova Fairfax Hospital
🇺🇸Falls Church, Virginia, United States
Mary Washington Hospital
🇺🇸Fredericksburg, Virginia, United States
Cardiovascular and Thoracic Surgery Associates
🇺🇸Arlington, Virginia, United States
Sentara Norfolk General Hospital
🇺🇸Norfolk, Virginia, United States
VA-Medical Center -Seattle Cardiology
🇺🇸Seattle, Washington, United States
Carillion Roanoke Hospital
🇺🇸Roanoke, Virginia, United States
FHS Research Center
🇺🇸Tacoma, Washington, United States
University of Washington
🇺🇸Seattle, Washington, United States
Appleton Medical Center
🇺🇸Appleton, Wisconsin, United States
Gundersen-Lutheran Hospital
🇺🇸La Crosse, Wisconsin, United States
Tacoma General Hospital
🇺🇸Tacoma, Washington, United States
Cardiovascular Research and Education Foundation, Inc.
🇺🇸Wausau, Wisconsin, United States
Cathy Metcalfe Research Consultants
🇨🇦Delta, British Columbia, Canada
University of Manitoba Health Science Centre
🇨🇦Winnipeg, Manitoba, Canada
Health Science Centre
🇨🇦Winnipeg, Manitoba, Canada
New Brunswick Heart Center
🇨🇦St. John, New Brunswick, Canada
General Hospital Health Science Center
🇨🇦St. John's, Newfoundland and Labrador, Canada
Sunnybrook & Women's College Health Science Centre
🇨🇦Toronto, Ontario, Canada
Dalhousie University
🇨🇦Halifax, Nova Scotia, Canada
McMaster Clinic
🇨🇦Hamilton, Ontario, Canada
Toronto General Hospital
🇨🇦Toronto, Ontario, Canada
Hopital Laval
🇨🇦Quebec City, Quebec, Canada
Royal Victoria Hospital
🇨🇦Montreal, Quebec, Canada
University of Montreal
🇨🇦Montreal, Quebec, Canada
Regina General Hospital
🇨🇦Regina, Saskatchewan, Canada
San Diego Cardiac Center
🇺🇸San Diego, California, United States
Abbott Northwestern Hospital
🇺🇸Minneapolis, Minnesota, United States
Park Nicollet Medical Center
🇺🇸Minneapolis, Minnesota, United States
University of Texas Health Science Center at San Antonio
🇺🇸San Antonio, Texas, United States
Duke University Medical Center
🇺🇸Durham, North Carolina, United States
South Texas VA Health Care
🇺🇸San Antonio, Texas, United States
South Texas Cardiovascular Consultants Clinical Research Center
🇺🇸San Antonio, Texas, United States
Kaiser Foundation Hospital
🇺🇸San Francisco, California, United States
UCSF Moffitt-Long Hospital
🇺🇸San Francisco, California, United States
Baystate Medical Center
🇺🇸Springfield, Massachusetts, United States
Washington University School of Medicine
🇺🇸St. Louis, Missouri, United States
New York Presbyterian Hospital
🇺🇸New York City, New York, United States
Good Samaritan Regional Medical Center
🇺🇸Phoenix, Arizona, United States
Oklahoma Foundation for Cardiovascular Research
🇺🇸Oklahoma City, Oklahoma, United States
University of Oklahoma
🇺🇸Oklahoma City, Oklahoma, United States
Integris Baptist Medical Center
🇺🇸Oklahoma City, Oklahoma, United States
Henry Ford Hospital
🇺🇸Detroit, Michigan, United States
Vancouver General Hospital
🇨🇦Vancouver, British Columbia, Canada
Baptist Medical Center Cardiology
🇺🇸Birmingham, Alabama, United States
University of Alabama at Birmingham
🇺🇸Birmingham, Alabama, United States
South Denver Cardiology Associates
🇺🇸Denver, Colorado, United States
Legacy Good Samaritan Hospital
🇺🇸Portland, Oregon, United States
Pepin Heart and Vascular Institute
🇺🇸Tampa, Florida, United States
Wisconsin Center for Clinical Research
🇺🇸Milwaukee, Wisconsin, United States
Medical College of Wisconsin
🇺🇸Milwaukee, Wisconsin, United States
Dayton Heart Center
🇺🇸Dayton, Ohio, United States
Northwestern University Medical Center
🇺🇸Chicago, Illinois, United States
North Ohio Heart Center
🇺🇸Sandusky, Ohio, United States
Northwest Surgical Associates
🇺🇸Portland, Oregon, United States
Straub Clinic and Hospital
🇺🇸Honolulu, Hawaii, United States
Kaiser Permanente Medical Center
🇺🇸Honolulu, Hawaii, United States
Iowa Heart Center - Laurel
🇺🇸Des Moines, Iowa, United States
Maimonides Medical Center
🇺🇸Brooklyn, New York, United States
St. Vincent's Medical Center
🇺🇸Indianapolis, Indiana, United States
University of Arkansas
🇺🇸Little Rock, Arkansas, United States
Dartmouth-Hitchcock Medical Center
🇺🇸Lebanon, New Hampshire, United States
Montreal Heart Institute
🇨🇦Montreal, Quebec, Canada
Georgetown University Hospital
🇺🇸Washington, District of Columbia, United States
Washington Hospital Center
🇺🇸Washington, District of Columbia, United States
VA Medical Center - Washington DC
🇺🇸Washington, District of Columbia, United States
Makenzie Health Science Center
🇨🇦Edmonton, Alberta, Canada
St. Paul's Hospital
🇨🇦Vancouver, British Columbia, Canada
Huntington Memorial Hospital
🇺🇸Los Angeles, California, United States
Fletcher Allen Health Care
🇺🇸Burlington, Vermont, United States
Seton Medical Center
🇺🇸Austin, Texas, United States
Mercy General Hospital
🇺🇸Sacramento, California, United States
Florida Heart Institute at Florida Hospital
🇺🇸Orlando, Florida, United States
Orlando Heart Center
🇺🇸Orlando, Florida, United States
University of Louisville
🇺🇸Louisville, Kentucky, United States
St. Luke's Hospital - Mid-America Heart Institute
🇺🇸Kansas City, Missouri, United States
West forest School of Medicine
🇺🇸Winston-Salem, North Carolina, United States
Turuo Infirmary
🇺🇸New Orleans, Louisiana, United States
Alton Ochsner Medical Foundation - Brent House
🇺🇸New Orleans, Louisiana, United States
Brackenridge Hospital
🇺🇸Austin, Texas, United States
Sinai Hospital of Baltimore
🇺🇸Baltimore, Maryland, United States
Washington Adventist Hospital
🇺🇸Takoma Park, Maryland, United States
Albert Einstein Hospital
🇺🇸Bronx, New York, United States
University of Arizona
🇺🇸Tucson, Arizona, United States
University of Rochester
🇺🇸Rochester, New York, United States