NCT03177330
Unknown
Not Applicable
Safety and Efficacy of Heparin Dosing Score Protocol for Anticoagulation During Polymyxin-B Hemoperfusion: a Retrospective Study
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Septic Shock
- Sponsor
- National Taiwan University Hospital
- Enrollment
- 30
- Locations
- 1
- Primary Endpoint
- premature cartridge clotting rate
- Last Updated
- 8 years ago
Overview
Brief Summary
Polymyxin B hemoperfusion (PMX-HP) is mainly used to remove endotoxins in septic shock patients with intra-abdominal infections. Because of the concerns of postoperative bleeding, physicians may hesitate to use anticoagulation in patients with septic shock within a few hours after an abdominal operation. We developed a heparin dosing score protocol for heparin dosage adjustment. The purpose of the study is to examine the safety and efficacy of the heparin dosing score protocol.
Investigators
Eligibility Criteria
Inclusion Criteria
- •intra-abdominal septic shock patients or documented Gram-negative bacterial septic shock patients who received polymyxin-B hemoperfusion in National Taiwan University Hospital during October 2013-December 2016
Exclusion Criteria
- •pregnant woman
- •patients with do-not-resuscitate declaration
- •uncontrolled bleeding within 24hr
Outcomes
Primary Outcomes
premature cartridge clotting rate
Time Frame: 2 hours
the incidence of premature cartridge clotting within 2hr
Secondary Outcomes
- bleeding event rate(24 hours)
Study Sites (1)
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