Building resources to improve treatment in two clinical priority areas – antibiotic prescribing for routine infections and treatment for frail elderly populations

Not Applicable

• Conditions: Primary care; Not Applicable

• Registration Number: ISRCTN16230629
• Lead Sponsor: niversity of Manchester

Brief Summary

2023 Protocol article in https://pubmed.ncbi.nlm.nih.gov/37607793/ (added 25/08/2023)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2021-11-01
• Last Update Posted: 4 September 2023
• Study Completion: 2023-10-30

Recruitment & Eligibility

• Status: Ongoing
• Sex: All
• Target Recruitment: 124

Inclusion Criteria

1. Any population of individuals whose data contribute to the Greater Manchester care record, Liverpool and Cheshire care record or the Yorkshire and Humber care record who have not opted out of secondary data use.
2. For the workshops/interviews/surveys any professional involved in the prescribing of antibiotics or providing guidance on such. The researchers will work with members of the public as a PPI activity with a core PPI group.
3. The intervention is applied at the practice level (this is also the legal entity for signing data sharing agreements with the data centres i.e. the data controller). Any general practice that has provided data to the data centres in the study with permission for secondary use or practice that consents to the use of data for research purposes is eligible to become a study site. When a general practice participates, this will imply that all their staff directly participate in the study and all their patients indirectly participate in the study.

Exclusion Criteria

1. The main exclusion criteria concern patients who have opted out of sharing their anonymised data for research. Their data will not be analysed.
2. The researchers will also not use any READ codes associated with data considered to be sensitive, such as sexually transmitted infections or infections following abortions

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Antibiotic sub-study: <br>The overall rate of antibiotic prescribing measured using electronic health records at baseline and 12 months<br><br>Frailty sub-study:<br>Prescribing rates in frail elderly measured using electronic health records at baseline and 12 months

Secondary Outcome Measures

Name	Time	Method
Antibiotic sub-study: <br>1. Infection-related complications as recorded in the primary care records such as pneumonia and lower respiratory tract infections (RTIs), peritonsillar abscess, mastoiditis, intracranial abscess, empyema, scarlet fever, pyelonephritis, septic arthritis, osteomyelitis, meningitis, toxic shock syndrome and septicaemia, and Lemierre syndrome<br>2. Rate of hospital admission for infection-related complications<br><br>Both measured using electronic health records at baseline and 12 months