Thromboelastometry in Liver Transplantation

Not Applicable

• Conditions: Coagulopathy; Liver Transplant Disorder

• Registration Number: NCT03011827
• Lead Sponsor: Hospital Clinic of Barcelona

Brief Summary

Thromboelastometry better assess coagulation than standard coagulation test in patients undergoing ortothopic liver transplantation. In a post-hoc analysis from a randomized study recently conducted by our group, presurgical values of MA10 Extem \< 35 mm are highly predictive of RBC administration , with no further improvement over MA10 Extem \>40 mm ; suggesting that MA10 Extem between 35-40 would be the optimal range to manage blood product administration. The aim of the study is to validate this result in a prospective cohort of patients submitted to ortothopic liver transplantation.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2017-01-04
• Study First Submitted QC: 2017-01-04
• Study First Posted: 2017-01-05
• Status Verified: 2019-08
• Study Start: 2019-08-01
• Last Update Submitted: 2019-08-06
• Last Update Posted: 2019-08-07
• Primary Completion: 2022-09
• Study Completion: 2022-10

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 65

Inclusion Criteria

• Presurgical hemoglobin < 13 d/L and clot firmness at 10 minutes Extem < 35 mm

Exclusion Criteria

• Previous thrombosis
• Antithrombotic treatment
• No consent

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
Red blood cell transfusion	until 24h after liver transplant

Secondary Outcome Measures

Name	Time	Method
Thrombosis	28 days after liver transplant	Thrombosis will be assessed clinically and confirmed by ultrasonographic exam

Trial Locations

Locations (2)

Hospital Universitari de Bellvitge; 🇪🇸 L'Hospitalet de Llobregat, Barcelona, Spain

Hospital de Cruces; 🇪🇸 Bilbao, Spain