Thromboelastometry in Liver Transplantation
- Conditions
- CoagulopathyLiver Transplant Disorder
- Interventions
- Other: Fibrinogen and/or platelets administration
- Registration Number
- NCT03011827
- Lead Sponsor
- Hospital Clinic of Barcelona
- Brief Summary
Thromboelastometry better assess coagulation than standard coagulation test in patients undergoing ortothopic liver transplantation. In a post-hoc analysis from a randomized study recently conducted by our group, presurgical values of MA10 Extem \< 35 mm are highly predictive of RBC administration , with no further improvement over MA10 Extem \>40 mm ; suggesting that MA10 Extem between 35-40 would be the optimal range to manage blood product administration. The aim of the study is to validate this result in a prospective cohort of patients submitted to ortothopic liver transplantation.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 65
- Presurgical hemoglobin < 13 d/L and clot firmness at 10 minutes Extem < 35 mm
- Previous thrombosis
- Antithrombotic treatment
- No consent
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Prospective cohort Fibrinogen and/or platelets administration Fibrinogen and/or platelet administration
- Primary Outcome Measures
Name Time Method Red blood cell transfusion until 24h after liver transplant
- Secondary Outcome Measures
Name Time Method Thrombosis 28 days after liver transplant Thrombosis will be assessed clinically and confirmed by ultrasonographic exam
Trial Locations
- Locations (2)
Hospital Universitari de Bellvitge
🇪🇸L'Hospitalet de Llobregat, Barcelona, Spain
Hospital de Cruces
🇪🇸Bilbao, Spain