Korean Hereditary Breast Cancer Study

• Conditions: Breast Cancer; Ovarian Cancer

• Registration Number: NCT00595348
• Lead Sponsor: Korean Breast Cancer Study Group

Brief Summary

1. To evaluate the prevalence of BRCA1/2 mutation of breast cancer patients with family history of breast/ovarian cancer.

2. To evaluate the prevalence of BRCA1/2 mutation of breast cancer patients without family history, but high risk of hereditary cancer.

3. To evaluate the prevalence of BRCA1/2 mutation of family member of BRCA1/2 mutation.

4. To evaluate the prevalence of ovarian cancer of population of above 3 groups.

Detailed Description

1. To find founder mutation in Korean

2. To correlation prevalence with risk evaluation

3. To find risk factors concerning life style

Study Timeline

• Study Start: 2007-11
• Study First Submitted: 2008-01-06
• Study First Submitted QC: 2008-01-15
• Study First Posted: 2008-01-16
• Status Verified: 2011-05
• Last Update Submitted: 2011-05-09
• Last Update Posted: 2011-05-11
• Primary Completion: 2012-05
• Study Completion: 2017-05

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 2250

Inclusion Criteria

• Over 19 years old
• Agree to this study
• Breast cancer patient with family history of breast/ovarian cancer (1 subgroup)
• Breast cancer patient; young age (<40), bilateral, male, combined ovarian (2 subgroup)
• Family members with 1, 2 subgroups (3 subgroup)

Exclusion Criteria

• Under 20 years old
• Unable to decide for oneself

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Find out the prevalence of BRCA1/2 mutation of high risk breast cancer patients	6 years

Trial Locations

Locations (1)

Department of Surgery, Breast & Endocrine Service Seoul National University Bundang Hospital; 🇰🇷 Seongnam-Si, Gyeonggi-do, Korea, Republic of