Comparative Evaluation of Effectiveness of Demineralized Freeze-Dried Bone Allografts (DFDBA) with Titanium Platelet Rich Fibrin (T-PRF) and Autologous Dentin Graft (ADG) with T-PRF in Alveolar Socket Preservation: A Randomised Control Trial.
试验速览
- 阶段
- Phase 3 4
- 状态
- 尚未招募
- 发起方
- 入组人数
- 16
- 试验地点
- 1
- 主要终点
- radiographic analysis, we will access new bone formation, change in sockets vertical alveolar bone
研究概览
简要总结
AIM - assess and compare the effectiveness of DFDBA with T-PRF and ADG with T-PRF in socket preservation using clinical, radiological and histomorphometric analysis.
OBJECTIVES- Comparison of the effectiveness of DFDBA with T-PRF and ADG and T-PRF in alveolar ridge preservation therapy in terms of the quantity of newly formed bone and residual graft material that is histologically retained after four months of healing.
METHODOLOGY- Sixteen patients having teeth indicated for extraction in maxilla and /or mandiblewill be selected. Eight patients in test group and eight patients in control group will be alloted. In test group ADG and T-PRF will be used and in control group DFDBA + T-PRF will be used.
EXPECTED OUTCOME
T-PRF along with Autologous dentin graft will lead to better radiographic bone fill and improved intrasocket measurements after 4 months of surgery.
CONCLUSION- The socket preservation procedure have been proven to be effective in maintaining the ridge dimensions after extractions.
socket preservation using ADG+ T-PRF may result in maintaing the alveolar ridge dimensions.
M
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- None
入排标准
- 年龄范围
- 18.00 Year(s) 至 65.00 Year(s)（—）
- 性别
- All
入选标准
- •Patients indicated for implant following extraction.
- •Because of reasons like, fracture of root, failure of endodontic treatment, resorption (internal and external), over-retained primary teeth, non-restorable carious lesions, residual roots.
- •A complete mouth plaque score of less than 25% indicates good oral hygiene.
- •Existence of a natural tooth in opposition 4) Adjacent teeth presence 5) Thick gingival biotype 6) The clinical and radiological appearance of the unbroken alveolar bone walls 7) 4 mm of bone radiographically at root apex 8) D-1, D-2 or D-3 bone quality.
排除标准
- •Patients with impaired systemic health that would interfere with the process involved with repair and healing of bones e.g. (Diabetes mellitus, Osteoporosis, Blood disorders, and Titanium allergy).
- •Significant differences in maxilla-mandibular space.
- •Presence of para functional habits such as bruxism or clenching.
- •Presence of proclined teeth, teeth with interdental spacing, rotated or mal-aligned anterior teeth.
- •History of alcoholism, excessive smoking or drug abuse.
- •D-4 bone quality.
- •Radiotherapy and chemotherapy history.
- •Debilitating tempro-mandibular joint pathosis.
- •Untreated dental diseases.
- •Pregnant and lactating mothers.
结局指标
主要结局
radiographic analysis, we will access new bone formation, change in sockets vertical alveolar bone
时间窗: four months post operatively
次要结局
- The main results are linear phenotypic dimensional changes, at baseline & four months after healing at two locations in the midfacial & midpalatal bone & soft tissue thickness.(After four months of surgery)
研究者
Shivani Prafulla Thakre
Sharad Pawar Dental College, Sawangi (Meghe)