Zoetermeer Study.
Completed
- Conditions
- Physical frailty
- Registration Number
- NL-OMON28735
- Lead Sponsor
- Schering Berlin, SBU FC & HT/Department HT
- Brief Summary
J Clin Endocrinol Metab. 2006 Oct;91(10):3988-91. Epub 2006 Jun 27.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 100
Inclusion Criteria
1. Men;
2. 70 years or older;
Exclusion Criteria
1. Severe arthropathic deformation of knee joint severly limiting mobility;
2. Severe systemic disease interfering with conduct of study or interpretation of results;
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. Isometric Grip Strength;<br<br>2. Leg Extension Power;<br /><br>3. Physical Performance (according to Guralnik).
- Secondary Outcome Measures
Name Time Method 1. Activities od Daily Living;<br /><br>2. Fragen of LiebensZufriedenheid (quality of life);<br /><br>3. Mini Mental State examination;<br /><br>4. Body composition;<br /><br>5. Bone density of hip;<br /><br>6. Bone metabolism;<br /><br>7. Hormonal parameters total testosterone, DHEA, DHEA-S, estradiol, estrone, SHBG, IGF-1, IGFBP, IGFBP3;<br /><br>8. Glucose, insulin HbA1c;<br /><br>9. Immunological parameters (lymphocyte sub-populations and surface markers);<br /><br>10. Lipid metabolism (HDL, LDL, triglycerides, cholesterol);<br /><br>11. Carotid intima-media thickness.