ED Lung Protective Ventilation to Reduce Complications

Completed

• Conditions: Mechanical Ventilation; Ventilator-associated Conditions; ARDS
• Interventions: Procedure: lung protective ventilation

• Registration Number: NCT02543554
• Lead Sponsor: Washington University School of Medicine

Brief Summary

Early mechanical ventilation, if delivered with injurious settings, can lead to pulmonary complications, such as acute respiratory distress syndrome (ARDS). Mechanical ventilation in the emergency department (ED) has been studied infrequently when compared to the intensive care unit; however, data suggests that ED-based mechanical ventilation has significant room for improvement and may also be a causative factor in ARDS incidence.

Detailed Description

This is a before-after study examining the impact of implementing lung protective ventilation in the emergency department.

Study Timeline

• Study Start: 2014-10
• Study First Submitted: 2015-08-28
• Study First Submitted QC: 2015-09-03
• Study First Posted: 2015-09-07
• Primary Completion: 2016-03
• Study Completion: 2016-03
• Status Verified: 2018-05
• Results First Submitted: 2018-05-04
• Results First Submitted QC: 2018-05-04
• Last Update Submitted: 2018-05-04
• Results First Posted: 2018-12-03
• Last Update Posted: 2018-12-03

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 1705

Inclusion Criteria

• mechanically ventilated via an endotracheal tube in the ED

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Exclusion Criteria

• death in the ED,
• death or discontinuation of ventilation within 24 hours,
• chronic mechanical ventilation,
• ARDS while in the ED
• transfer to another hospital.

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Intervention group	lung protective ventilation	mechanically ventilated patients after implementation of ED lung protective ventilation

Primary Outcome Measures

Name	Time	Method
Number of Patients That Experience Pulmonary Complications After Admission From the Emergency Department	7 days

Secondary Outcome Measures

Name	Time	Method
Number of Patients That Die During the Hospitalization	Patients will be followed for the duration of hospital stay

Trial Locations

Locations (1)

Washinton University School of Medicine in St. Louis; 🇺🇸 Saint Louis, Missouri, United States