Study Of Venetoclax Tablet With Intravenous or Subcutaneous Azacitidine to Assess Change in Disease Activity In Adult Participants With Newly Diagnosed Higher-Risk Myelodysplastic Syndrome
- Conditions
- Myelodysplastic Syndrome (MDS)
- Interventions
- Registration Number
- NCT04401748
- Lead Sponsor
- AbbVie
- Brief Summary
Myelodysplastic Syndrome (MDS) is a group of disorders that gradually affect the ability of a person's bone marrow (semi-liquid tissue present in many bones like backbones) to produce normal blood cells. Some people with MDS have a risk of the disease progressing to acute myeloid leukemia (AML), and a risk of death from the disease itself. Symptoms of MDS include fatigue, shortness of breath, unusual paleness due to anemia (low red blood cell count), easy or unusual bruising, and red spots just beneath the skin caused by bleeding. The purpose of this study is to see how safe and effective venetoclax and azacitidine (AZA) combination are when compared to AZA and a placebo (contains no medicine), in participants with newly diagnosed higher-risk MDS.
Venetoclax is an investigational drug being developed for the treatment of MDS. The study consists of two treatment arms - In one arm, participants will receive venetoclax and AZA. In another arm, participants will receive AZA and placebo. Adult participants with newly diagnosed higher-risk MDS will be enrolled. Around 500 participants will be enrolled in approximately 220 sites worldwide.
Participants in one arm will receive oral doses of venetoclax tablet and intravenous (infusion in the vein) or subcutaneous (given under the skin) AZA solution. Participants in another arm will receive oral doses of placebo tablet and intravenous or subcutaneous AZA solution.
There may be higher treatment burden for participants in this trial compared to their standard of care. Participants will attend regular visits during the course of the study at a hospital or clinic. The effect of the treatment will be checked by medical assessments, blood and bone marrow tests, checking for side effects, and completing questionnaires.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ACTIVE_NOT_RECRUITING
- Sex
- All
- Target Recruitment
- 531
-
Participants with a diagnosis of Myelodysplastic Syndrome (MDS) according to the 2016 World Health Organization (WHO) classification wtih presence of < 20% bone marrow blasts per marrow biopsy/aspirate at screening.
-
Participants must meet the following disease activity criteria:
- Overall Revised International Prognostic Scoring System (IPSS-R) score > 3 (intermediate, high or very high).
- Eastern Cooperative Oncology Group (ECOG) performance status of <= 2.
- Hematopoietic stem cell transplant (HSCT) eligible with no pre-arranged HSCT at the time of Study Day 1, or HSCT ineligible without plan for HSCT at the time of Study Day 1.
- Prior therapy for MDS with any hypomethylating agent, chemotherapy, or allogenic stem cell transplantation.
- Prior diagnosis of therapy-related MDS (t-MDS), MDS evolving from a pre-existing myeloproliferative neoplasm (MPN), MDS/MPN including chronic myelomonocytic leukemia (CMML), atypical chronic myeloid leukemia (aCML), juvenile myelomonocytic leukemia (JMML) and unclassifiable MDS/MPN.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Arm 2: Placebo + Azacitidine Placebo Participants will receive placebo once daily (QD) (Days 1-14) in combination with AZA QD (7 days of the first 9 days) of each 28 day cycle. Arm 1: Venetoclax + Azacitidine (AZA) Venetoclax Participants will receive venetoclax once daily (QD) (Days 1-14) in combination with AZA QD (7 days of the first 9 days) of each 28 day cycle. Arm 1: Venetoclax + Azacitidine (AZA) Azacitidine Participants will receive venetoclax once daily (QD) (Days 1-14) in combination with AZA QD (7 days of the first 9 days) of each 28 day cycle. Arm 2: Placebo + Azacitidine Azacitidine Participants will receive placebo once daily (QD) (Days 1-14) in combination with AZA QD (7 days of the first 9 days) of each 28 day cycle.
- Primary Outcome Measures
Name Time Method Overall survival (OS) Up To 5 Years OS is defined as the number of days from the date of randomization to the date of death of any cause, or last known date to be alive.
- Secondary Outcome Measures
Name Time Method Percentage of Participants Achieving Overall Hematological Improvement (HI) Up to 5 Years Overall HI is defined as achieving the response of HI-platelet or HI-neutrophil, or HI-erythroid at any time point during the study prior to post-treatment therapy per the modified IWG 2006 criteria for MDS.
Modified Overall Response (mOR) Up To 5 Years mOR \[complete remission (CR) + marrow complete remission (mCR) + partial response (PR)\] is defined as achieving a CR, mCR, or PR at any time point during the study per the modified International Working Group (IWG) 2006 criteria for myelodysplastic syndrome (MDS).
Percentage of Participants Achieving Transfusion Independence (TI) Who are Transfusion Dependent at Baseline Up To 5 Years TI is when the participants who were transfusion dependent on red blood cell (RBC) and/or Platelet at baseline achieve transfusion independence post baseline. TI is a period of at least 56 days with no transfusion after the date of the first dose of study drug to the last dose of study drug + 30 days, or 1 day before the date of progressive disease/ relapse from CR or PR per the modified IWG 2006 criteria for MDS, or 1 day before the initiation of post-treatment therapy or 1 day before death, whichever is earliest.
Complete Remission (CR) Up To 36 Months CR is defined as achieving a complete remission at any time point during the study per the modified International Working Group (IWG) 2006 criteria for myelodysplastic syndrome (MDS).
Time to Deterioration in Physical Functioning as Measured by Physical Functioning Domain of the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30) Scale Up To 5 Years Time to deterioration in physical functioning, as measured by the EORTC QLQ-C30 physical functioning score is defined as the time from the date of randomization to the date of death of any cause, or the first time worsening of score from baseline \>= a pre-specified threshold. Participants rate items on a 4-point scale, with 1 as "not at all" and 4 as "very much."
Change in Patient-Reported Outcomes Measurement Information System (PROMIS)-Fatigue Short Form (SF) 7a Scale Score Up To 5 Years Fatigue will be assessed using the PROMIS Fatigue SF 7a Global Fatigue Score. PROMIS Fatigue SF 7a is a 7-item questionnaire that assesses the impact and experience of fatigue over the past 7 days. Participants rate items on a 5-point scale, with 1 as "never" an 5 as "always".
Overall Response (OR) Up To 5 Years OR \[complete remission (CR) + partial response (PR)\] is defined as achieving a CR or PR at any time point during the study per the modified IWG 2006 criteria for MDS.
Trial Locations
- Locations (220)
Texas Oncology- Baylor Charles A. Sammons Cancer Center /ID# 223727
🇺🇸Dallas, Texas, United States
UPMC Hillman Cancer Ctr /ID# 223201
🇺🇸Pittsburgh, Pennsylvania, United States
China Medical University Hospital /ID# 218987
🇨🇳Taichung, Taiwan
Northwestern University Feinberg School of Medicine /ID# 220843
🇺🇸Chicago, Illinois, United States
Comprehensive Cancer Centers of Nevada - Horizon Ridge /ID# 222635
🇺🇸Henderson, Nevada, United States
Ingalls Memorial Hosp /ID# 220844
🇺🇸Harvey, Illinois, United States
St. Luke's Mountain State Tumor Institute /ID# 220838
🇺🇸Boise, Idaho, United States
Maryland Oncology Hematology /ID# 223776
🇺🇸Columbia, Maryland, United States
University of California, Los Angeles /ID# 221760
🇺🇸Los Angeles, California, United States
Massachusetts General Hospital /ID# 225068
🇺🇸Boston, Massachusetts, United States
Helen F. Graham Cancer Center & Research Institute /ID# 223731
🇺🇸Newark, Delaware, United States
Florida Cancer Specialists - North /ID# 221318
🇺🇸Saint Petersburg, Florida, United States
Duplicate_Rush University Medical Center /ID# 221007
🇺🇸Chicago, Illinois, United States
New York Oncology Hematology - Albany Cancer Center /ID# 223778
🇺🇸Albany, New York, United States
Stony Brook University Hospital /ID# 224450
🇺🇸Stony Brook, New York, United States
Rocky Mountain Cancer Centers - Boulder /ID# 223723
🇺🇸Boulder, Colorado, United States
Florida Cancer Specialists - East /ID# 221317
🇺🇸West Palm Beach, Florida, United States
Beth Israel Deaconess Medical Center /ID# 225069
🇺🇸Boston, Massachusetts, United States
Florida Cancer Specialists - Fort Myers /ID# 221319
🇺🇸Fort Myers, Florida, United States
PIH Health Whittier Hospital /ID# 222647
🇺🇸Whittier, California, United States
University at Buffalo /ID# 221206
🇺🇸Buffalo, New York, United States
Dana-Farber Cancer Institute /ID# 219162
🇺🇸Boston, Massachusetts, United States
Duplicate_Parkview Cancer Institute /ID# 223620
🇺🇸Fort Wayne, Indiana, United States
Hematology/Oncology Clinic /ID# 224257
🇺🇸Baton Rouge, Louisiana, United States
Cancer & Hematology Centers /ID# 220848
🇺🇸Grand Rapids, Michigan, United States
Pontchartrain Cancer Center - Covington /ID# 221005
🇺🇸Covington, Louisiana, United States
Weill Cornell Medical College /ID# 222898
🇺🇸New York, New York, United States
Duplicate_Providence Medical Foundation /ID# 222633
🇺🇸Fullerton, California, United States
Florida Cancer Specialists - Panhandle /ID# 221315
🇺🇸Tallahassee, Florida, United States
Texas Oncology - Medical City Dallas /ID# 223725
🇺🇸Dallas, Texas, United States
Illinois Cancer Care, PC /ID# 220840
🇺🇸Peoria, Illinois, United States
Memorial Healthcare System /ID# 222703
🇺🇸Hollywood, Florida, United States
Texas Oncology - Northeast Texas /ID# 223734
🇺🇸Tyler, Texas, United States
Torrance Memorial Physician Network Cancer Care /ID# 222702
🇺🇸Torrance, California, United States
Bend Memorial Clinic /ID# 220999
🇺🇸Bend, Oregon, United States
Metro Minnesota Community Oncology Research Consortium (MMCORC) /ID# 221321
🇺🇸Saint Louis Park, Minnesota, United States
Titan Health Partners LLC, d/b/a Astera Cancer Care /ID# 221003
🇺🇸East Brunswick, New Jersey, United States
The Valley Hospital /ID# 232337
🇺🇸Paramus, New Jersey, United States
Virginia Cancer Specialists - Gainesville /ID# 223726
🇺🇸Gainesville, Virginia, United States
Duplicate_Blacktown Hospital /ID# 234079
🇦🇺Blacktown, New South Wales, Australia
VA Puget Sound Health Care System /ID# 221358
🇺🇸Seattle, Washington, United States
Ordensklinikum Linz GmbH Elisabethinen /ID# 221387
🇦🇹Linz, Oberoesterreich, Austria
Medizinische Universitaet Wien /ID# 221446
🇦🇹Vienna, Wien, Austria
MD Anderson Cancer Center at Texas Medical Center /ID# 219163
🇺🇸Houston, Texas, United States
Novant Health Presbyterian Medical Center /ID# 222561
🇺🇸Charlotte, North Carolina, United States
Baylor Scott & White Medical Center- Temple /ID# 221332
🇺🇸Temple, Texas, United States
Willamette Valley Cancer Institute and Research Center /ID# 223733
🇺🇸Eugene, Oregon, United States
Austin Health /ID# 221807
🇦🇺Heidelberg, Victoria, Australia
UZ Gent /ID# 218767
🇧🇪Gent, Oost-Vlaanderen, Belgium
AZ Sint-Jan Brugge /ID# 218212
🇧🇪Brugge, Belgium
Port Macquarie Base Hospital /ID# 234078
🇦🇺Port Macquarie, New South Wales, Australia
Tennessee Oncology - Chattanooga / McCallie /ID# 221311
🇺🇸Chattanooga, Tennessee, United States
Ottawa Hospital Research Institute /ID# 219105
🇨🇦Ottawa, Ontario, Canada
Hospital Universitário Pedro Ernesto /ID# 223080
🇧🇷Rio de Janeiro, Brazil
Texas Oncology - Forth Worth /ID# 223777
🇺🇸Fort Worth, Texas, United States
Avera Cancer Institute /ID# 243461
🇺🇸Sioux Falls, South Dakota, United States
Hospital Universitario Walter Cantidio /ID# 223434
🇧🇷Fortaleza, Ceara, Brazil
Royal Adelaide Hospital /ID# 221805
🇦🇺Adelaide, South Australia, Australia
McGill University Health Center Research Institute /ID# 222519
🇨🇦Montreal, Quebec, Canada
CIUSSS du Nord-de-l'ile-de-Montréal_Hopital du Sacré-Coeur de Montréal /ID# 218973
🇨🇦Montreal, Quebec, Canada
Sociedade Beneficente Israelita Brasileira Hospital Albert Einstein /ID# 221370
🇧🇷São Paulo, Sao Paulo, Brazil
IRCCS Azienda Ospedaliero-Universitaria di Bologna /ID# 220810
🇮🇹Bologna, Italy
CHUQ- Hôpital de l'Enfant-Jesus /ID# 221200
🇨🇦Quebec City, Quebec, Canada
Gold coast University Hospital /ID# 222606
🇦🇺SouthPort, Queensland, Australia
Zhujiang Hospital of Southern Medical University /ID# 222071
🇨🇳Guangzhou, Guangdong, China
Fakultni Nemocnice Ostrava /ID# 219143
🇨🇿Ostrava, Czechia
Nagoya University Hospital /ID# 221566
🇯🇵Nagoya-shi, Aichi, Japan
Klinikum rechts der Isar /ID# 221170
🇩🇪Munich, Germany
Hopital de la Conception /ID# 224882
🇫🇷Marseille, Bouches-du-Rhone, France
Duplicate_Debreceni Egyetem Klinikai Kozpont /ID# 221702
🇭🇺Debrecen, Hajdu-Bihar, Hungary
Tel Aviv Sourasky Medical Center /ID# 221896
🇮🇱Tel Aviv, Tel-Aviv, Israel
Sunnybrook Health Sciences Ctr /ID# 219103
🇨🇦Toronto, Ontario, Canada
Saitama Medical Center /ID# 222016
🇯🇵Kawagoe-shi, Saitama, Japan
CHRU Lille - Hopital Claude Huriez /ID# 220991
🇫🇷Lille, Nord, France
Azienda Ospedaliera di Rilievo Nazionale Antonio Cardarelli /ID# 220816
🇮🇹Napoli, Italy
St Vincent's Hospital Melbourne /ID# 221809
🇦🇺Fitzroy Melbourne, Victoria, Australia
University of Fukui University Hospital /ID# 221568
🇯🇵吉田郡, Fukui, Japan
Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao /ID# 221339
🇧🇷Sao Paulo, Brazil
Hadassah Medical Center-Hebrew University /ID# 222006
🇮🇱Jerusalem, Yerushalayim, Israel
Sapporo Hokuyu Hospital /ID# 222133
🇯🇵Sapporo-shi, Hokkaido, Japan
Union Hospital affiliated to Tongji Medical College of Huazhong University of Sc /ID# 221475
🇨🇳Wuhan, Hubei, China
Stauferklinikum Schwaebisch Gmuend /ID# 224917
🇩🇪Mutlangen, Baden-Wuerttemberg, Germany
CH Henri Duffaut /ID# 225185
🇫🇷Avignon CEDEX 9, Vaucluse, France
Istituto Clinico Humanitas /ID# 220815
🇮🇹Rozzano, Milano, Italy
Azienda Ospedaliero-Universitaria Sant'Andrea /ID# 220819
🇮🇹Rome, Italy
Universitatsklinikum Mannheim /ID# 221172
🇩🇪Mannheim, Baden-Wuerttemberg, Germany
Somogy Varmegyei Kaposi Mor Oktato Korhaz /ID# 221703
🇭🇺Kaposvár, Somogy, Hungary
Kobe City Medical Center General Hospital /ID# 221977
🇯🇵Kobe-shi, Hyogo, Japan
National Hospital Organization Mito Medical Center /ID# 222278
🇯🇵Higashi Ibaraki-gun, Ibaraki, Japan
Centre Henri Becquerel /ID# 220986
🇫🇷Rouen, France
Szegedi Tudományegyetem /ID# 221705
🇭🇺Szeged, Hungary
Universitaetsklinikum Leipzig /ID# 221168
🇩🇪Leipzig, Sachsen, Germany
Shaare Zedek Medical Center /ID# 233181
🇮🇱Jerusalem, Yerushalayim, Israel
Fakultni nemocnice Brno /ID# 221351
🇨🇿Brno, Czechia
Ustav hematologie a krevni transfuze /ID# 221350
🇨🇿Praha, Czechia
Vseobecna fakultni nemocnice v Praze /ID# 221229
🇨🇿Praha, Czechia
CHU Grenoble - Hopital Michallon /ID# 220988
🇫🇷La Tronche, Isere, France
Universitaetsklinikum Koeln /ID# 234219
🇩🇪Köln, Nordrhein-Westfalen, Germany
Fejér Vármegyei Szent György Egyetemi Oktató Kórház /ID# 222953
🇭🇺Szekesfehervar, Fejer, Hungary
AP-HP - Hopital Saint-Louis /ID# 222075
🇫🇷Paris, France
West China Hospital, Sichuan University /ID# 221601
🇨🇳Chengdu, Sichuan, China
Tohoku University Hospital /ID# 221976
🇯🇵Sendai-shi, Miyagi, Japan
Kyushu University Hospital /ID# 223473
🇯🇵Fukuoka-shi, Fukuoka, Japan
Fakultni nemocnice Hradec Kralove /ID# 221163
🇨🇿Hradec Kralove, Czechia
Charite Universitaetsklinikum Berlin - Campus Benjamin Franklin /ID# 221189
🇩🇪Berlin, Germany
Fakultni nemocnice Plzen /ID# 221162
🇨🇿Plzen, Czechia
CHU de Nice - Hôpital Archet 1 /ID# 220992
🇫🇷Nice, Alpes-Maritimes, France
Grande Ospedale Metropolitano Bianchi Melacrino Morelli /ID# 220818
🇮🇹Reggio Calabria, Italy
Medizinische Hochschule Hannover /ID# 221173
🇩🇪Hannover, Germany
The Chaim Sheba Medical Center /ID# 221110
🇮🇱Ramat Gan, Tel-Aviv, Israel
Chugoku Central Hospital /ID# 222955
🇯🇵Fukuyama, Hiroshima, Japan
Fukushima Medical University Hospital /ID# 222015
🇯🇵Fukushima-shi, Fukushima, Japan
Rambam Health Care Campus /ID# 221083
🇮🇱Haifa, H_efa, Israel
Seoul National University Bundang Hospital /ID# 221695
🇰🇷Seongnam-si, Gyeonggido, Korea, Republic of
Yamagata University Hospital /ID# 221574
🇯🇵Yamagata-shi, Yamagata, Japan
Wojewódzki Szpital Specjalistyczny im. M.Kopernika w Łodzi /ID# 221784
🇵🇱Lodz, Lodzkie, Poland
VA Caribbean Healthcare System /ID# 221012
🇵🇷San Juan, Puerto Rico
Medisch Spectrum Twente /ID# 223012
🇳🇱Enschede, Netherlands
Hospital General Universitario Gregorio Maranon /ID# 221271
🇪🇸Madrid, Spain
Hospital Universitario Reina Sofia /ID# 221273
🇪🇸Córdoba, Cordoba, Spain
Uniwersyteckie Centrum Kliniczne /ID# 222069
🇵🇱Gdansk, Pomorskie, Poland
Chi-Mei Medical Center /ID# 218991
🇨🇳Tainan, Taiwan
Seoul National University Hospital /ID# 221226
🇰🇷Seoul, Korea, Republic of
Maxima Medisch Centrum /ID# 223010
🇳🇱Eindhoven, Netherlands
Isala /ID# 223011
🇳🇱Zwolle, Netherlands
Pusan National University Hospital /ID# 232353
🇰🇷Busan, Korea, Republic of
Ondokuz mayis University Facul /ID# 222091
🇹🇷Samsun, Turkey
Acibadem Maslak Hastanesi /ID# 222072
🇹🇷Tuzla, Turkey
University Hospitals Bristol /ID# 222510
🇬🇧Bristol, Bristol, City Of, United Kingdom
Uniwersytecki Szpital Kliniczny Nr 1 w Lublinie /ID# 221667
🇵🇱Lublin, Lubelskie, Poland
Derriford Hospital and the Royal Eye Infirmary /ID# 222514
🇬🇧Plymouth, Devon, United Kingdom
Clinic UZI 4D /ID# 221215
🇷🇺Pyatigorsk, Stavropol Skiy Kray, Russian Federation
University College London Hospitals NHS Foundation Trust /ID# 221240
🇬🇧London, United Kingdom
Hospital Universitario Virgen del Rocio /ID# 221276
🇪🇸Sevilla, Spain
Hospital Universitario 12 de Octubre /ID# 221272
🇪🇸Madrid, Spain
Hospital Universitario Quirón Salud Madrid /ID# 221275
🇪🇸Pozuelo de Alarcón, Madrid, Spain
Erasmus Medisch Centrum /ID# 218937
🇳🇱Rotterdam, Netherlands
Pratia Onkologia Katowice /ID# 224728
🇵🇱Katowice, Poland
Pan American Center for Oncology Trials, LLC /ID# 221010
🇵🇷Rio Piedras, Puerto Rico
NHS Grampian /ID# 222509
🇬🇧Aberdeen, United Kingdom
Hospital n.a. V.V. Veresaev /ID# 225435
🇷🇺Moscow, Russian Federation
MMCC Kommunarka /ID# 221213
🇷🇺Moscow, Russian Federation
MTZ Clinical Research Powered by Pratia /ID# 221354
🇵🇱Warszawa, Mazowieckie, Poland
Hospital Erasto Gaertner /ID# 221341
🇵🇷Curitiba, Puerto Rico
Akdeniz Universitesi Tip Fakul /ID# 222095
🇹🇷Antalya, Turkey
Republican hospital named after V.A. Baranov /ID# 221214
🇷🇺Petrozavodsk, Russian Federation
Oxford University Hospitals NHS Foundation Trust /ID# 221231
🇬🇧Oxford, Oxfordshire, United Kingdom
Hacettepe University Faculty of Medicine /ID# 222094
🇹🇷Ankara, Turkey
Ankara City Hospital /ID# 222093
🇹🇷Ankara, Turkey
Hospital Universitario y Politecnico La Fe /ID# 221270
🇪🇸Valencia, Spain
Maastricht Universitair Medisch Centrum /ID# 221630
🇳🇱Maastricht, Netherlands
Oncology Hematology Care, Inc. /ID# 223724
🇺🇸Cincinnati, Ohio, United States
Texas Oncology - San Antonio Medical Center /ID# 223728
🇺🇸San Antonio, Texas, United States
Université Catholique de Louvain-Namur - Centre Hospitalier Universitaire Dinant /ID# 219064
🇧🇪Yvoir, Namur, Belgium
Tennessee Oncology-Nashville Centennial /ID# 220854
🇺🇸Nashville, Tennessee, United States
Lanzhou University Second Hospital /ID# 225980
🇨🇳Lanzhou, Gansu, China
Guangdong Provincial People's Hospital /ID# 221442
🇨🇳Guangzhou, Guangdong, China
Nanfang Hospital of Southern Medical University /ID# 224566
🇨🇳Guangzhou, Guangdong, China
The Second Hospital of Hebei Medical University /ID# 222919
🇨🇳Shijiazhuang, Hebei, China
Tongji Hospital Tongji Medical College of HUST /ID# 221474
🇨🇳Wuhan, Hubei, China
People's Hospital of Henan Province /ID# 225790
🇨🇳Zhengzhou, Henan, China
Henan Cancer Hospital /ID# 221447
🇨🇳Zhengzhou, Henan, China
Jiangsu Province Hospital /ID# 221342
🇨🇳Nanjing, Jiangsu, China
Zhongda Hospital Southeast University /ID# 221849
🇨🇳Nanjing, Jiangsu, China
The First Affiliated Hospital of Soochow University /ID# 221640
🇨🇳Suzhou, Jiangsu, China
The First Affiliated Hospital of Nanchang University /ID# 225983
🇨🇳Nanchang, Jiangxi, China
Shanghai Sixth People's Hospital /ID# 221546
🇨🇳Shanghai, Shanghai, China
Shaanxi Provincial people's Hospital /ID# 225728
🇨🇳Xi'an, Shaanxi, China
Shengjing Hospital of China Medical University /ID# 222945
🇨🇳Shenyang, Liaoning, China
Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sc /ID# 221567
🇨🇳Tianjin, Tianjin, China
The First Affiliated Hospital, Zhejiang University School of Medicine /ID# 221494
🇨🇳Hangzhou, Zhejiang, China
Sir Run Run Shaw Hospital Zhejiang University School of Medicine /ID# 225982
🇨🇳Hangzhou, Zhejiang, China
Peking University International Hospital /ID# 222987
🇨🇳Beijing, China
The Fourth Affiliated Hospital Zhejiang University School of Medicine /ID# 225918
🇨🇳Yiwu, Zhejiang, China
Tianjin Medical University General Hospital /ID# 226810
🇨🇳Tianjin, China
Aiiku Hospital /ID# 222351
🇯🇵Sapporo, Hokkaido, Japan
Nagasaki University Hospital /ID# 222241
🇯🇵Nagasaki-shi, Nagasaki, Japan
Kindai University Hospital /ID# 222284
🇯🇵Osakasayama-shi, Osaka, Japan
Cancer Center of Kansas /ID# 222648
🇺🇸Wichita, Kansas, United States
Utah Cancer Specialists Salt Lake Clinic /ID# 219160
🇺🇸Salt Lake City, Utah, United States
Universitaetsklinikum Duesseldorf /ID# 221169
🇩🇪Düsseldorf, Nordrhein-Westfalen, Germany
Szabolcs-Szatmar-Bereg Varmegyei Oktatokorhaz /ID# 221704
🇭🇺Nyiregyhaza, Szabolcs-Szatmar-Bereg, Hungary
Rabin Medical Center /ID# 221184
🇮🇱Haifa, Israel
Okayama Medical Center /ID# 222310
🇯🇵Okayama-shi, Okayama, Japan
Yonsei University Health System Severance Hospital /ID# 233171
🇰🇷Seoul, Seoul Teugbyeolsi, Korea, Republic of
Asan Medical Center /ID# 221227
🇰🇷Seoul, Seoul Teugbyeolsi, Korea, Republic of
Samsung Medical Center /ID# 221224
🇰🇷Seoul, Korea, Republic of
Lux Med Onkologia - Szpital Szamocka /Id# 222203
🇵🇱Warszawa, Mazowieckie, Poland
Almazov National Medical Research Centre /ID# 221449
🇷🇺Sankt-Peterburg, Russian Federation
Kaluga Regional Clinical Hospital /ID# 221211
🇷🇺Kaluga, Kaluzhskaya Oblast, Russian Federation
Hospital Universitario Germans Trias i Pujol /ID# 221274
🇪🇸Badalona, Barcelona, Spain
Hospital Universitario Vall d'Hebron /ID# 221323
🇪🇸Barcelona, Spain
Kaohsiung Chang Gung Memorial Hospital /ID# 223573
🇨🇳Kaohsiung City, Kaohsiung, Taiwan
Duplicate_Erciyes University Medical Fac /ID# 222090
🇹🇷Melikgazi, Kayseri, Turkey
Hospital Universitario de Salamanca /ID# 221297
🇪🇸Salamanca, Spain
University Hospitals Dorset NHS Foundation Trust /ID# 221237
🇬🇧Poole, Dorset, United Kingdom
University Hospitals Birmingham NHS Foundation Trust /ID# 221233
🇬🇧Birmingham, United Kingdom
VA Ann Arbor Healthcare System /ID# 221365
🇺🇸Ann Arbor, Michigan, United States
Novant Health Forsyth Medical Center /ID# 221004
🇺🇸Winston-Salem, North Carolina, United States
Virginia Commonwealth University Medical Center Main Hospital /ID# 221590
🇺🇸Richmond, Virginia, United States
Virginia Cancer Institute at Reynolds Crossing /ID# 221002
🇺🇸Richmond, Virginia, United States
Yale University School of Medicine /ID# 222764
🇺🇸New Haven, Connecticut, United States
MidAmerica Division, Inc. /ID# 221895
🇺🇸Kansas City, Missouri, United States
Hanusch Krankenhaus /ID# 221093
🇦🇹Wien, Austria
Hospital La Louviere Site Jolimont - Helora /ID# 218921
🇧🇪La Louvière, Hainaut, Belgium
Centre Hospitalier Universitaire de Bordeaux /ID# 220989
🇫🇷Pessac CEDEX, Gironde, France
Szpital Uniwersytecki nr 2 im. dr. Jana Biziela /ID# 233321
🇵🇱Bydgoszcz, Kujawsko-pomorskie, Poland
CHU de Nantes, Hotel Dieu -HME /ID# 222074
🇫🇷Nantes, Pays-de-la-Loire, France
Klinikum Wels-Grieskirchen GmbH /ID# 221386
🇦🇹Wels, Oberoesterreich, Austria
Landeskrankenhaus Salzburg-Universitaetsklinikum der PMU (LKH) /ID# 221092
🇦🇹Salzburg, Austria
National Cheng Kung University Hospital /ID# 218989
🇨🇳Tainan, Taiwan
BC Cancer - Surrey /ID# 219098
🇨🇦Surrey, British Columbia, Canada
Cardiff & Vale University Health Board /ID# 221236
🇬🇧Cardiff, Wales, United Kingdom
NTT Medical Center Tokyo /ID# 222365
🇯🇵Shinagawa-ku, Tokyo, Japan
ZNA Middelheim /ID# 218907
🇧🇪Antwerp, Belgium
Cliniques Universitaires UCL Saint-Luc /ID# 219066
🇧🇪Woluwe-Saint-Lambert, Bruxelles-Capitale, Belgium
Universitair Ziekenhuis Leuven /ID# 218905
🇧🇪Leuven, Vlaams-Brabant, Belgium
Texas Oncology - Austin Midtown /ID# 223729
🇺🇸Austin, Texas, United States
St George Hospital /ID# 221810
🇦🇺Kogarah, New South Wales, Australia
The Royal Marsden NHS Foundation Trust /ID# 221232
🇬🇧London, United Kingdom
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