Influence of Dextroketamine on Brain Electrical Activity Monitoring during Total Venous Anesthesia
- Conditions
- ElectroencephalographyAnesthesia, GeneralE03.155
- Registration Number
- RBR-7qmdrhy
- Lead Sponsor
- Hospital São Carlos
- Brief Summary
Background: S-ketamine (SK) plays an important role in the modulation of pain in surgical patients. However, its intraoperative use may not validate the anesthetic adequacy indexes based on the electroencephalogram. Objetive: The aim of this study was to evaluate the parameters derived from EEG: BIS and electromyographic activity (EMG) in relation to varied doses of S-ketamine. Methodos: Fourty adult participants, both sexes, aged between 20 and 45 years, undergoing general venous anesthesia with effector site-controlled infusion, with BIS maintained between 45 and 55, before the SK, were randomly distributed in 5 equal groups. In group k0, control participants did not receive SK; all the k1, k2, k3 and k4 groups received an SK iv. bolus dose of 200µg.kg - 1, then each group received infusion doses of 100 µg.kg -1 .h -1 ; 200 µg.kg -1 .h -1 ; 300 µg.kg -1 .h -1 e 400 µg.kg -1 .h -1 , respectively. In each group, 11 moments were evaluated: M0 – before anesthetic induction; M1 – 10 minutes after stabilization of BIS anesthesia between 45 and 55 (with target of 50); M2 – 3 minutes after SK; M3 – 6 minutes after SK; M4 – 9 min after SK; M5 – 12 minutes after SK; M6 – 15 minutes after SK; M7 – 18 minutes after SK; M8 - 21 minutes after SK; M9 – 24 minutes after SK and M10 – 27 minutes after SK. At all times were recorded the values of: BIS and EMG. The electroencephalographic data obtained were analyzed using ANOVA for repeated measures and p-value adjusted for multiple comparisons by the Tukey test, considering as significant, p <0.05. Results: Comparing mean values of BIS and EMG between all groups, at each time point, no significant changes were observed (p> 0.05) after moment M0. Conclusion: Electroencephalographic parameters (BIS and EMG) are not significantly influenced whe this SK infusion model and total intravenous anesthesia are performed
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruitment completed
- Sex
- Not specified
- Target Recruitment
- Not specified
patients both genders; undergoing elective operations under general anesthesia; physical status P1 (American Society of Anesthesiologists); ages between 20 and 45 years and; body mass indexes between 21 and 26 kg.m-2
Patients with neurological disease; recent use of drugs that may alter the electroencephalogram.
Study & Design
- Study Type
- Intervention
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method