NCT01138683已完成3 期
Cardiorenal Interactions During Treatment of Acute Decompensated Heart Failure: Diuretics Versus Ultrafiltration
适应症
干预措施
相关药物
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 入组人数
- 1
- 试验地点
- 1
- 主要终点
- Incidence of AKI and determining factors in patients with acute decompensated heart failure with treated with ultrafiltration versus diuretics
研究概览
简要总结
The CRUF trial is a prospective randomized monocentric trial comparing different impact of diuretics versus ultrafiltration on renal congestion, plasma refill rate, echocardiographic filling pressures, neurohormonal activation and biomarkers of Acute Kidney Injury (AKI).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •>18 years old
- •Severe systolic heart failure with ejection fraction <40%
- •And Hospitalisation for decompensated heart failure
- •And New York Heart Association (NYHA) III or IV
- •And 1 of the following:
- •Jugular vein distension>6cm
- •Tissue Doppler mitral annulus lateral>12 or medial>15
- •Chest X-ray: pulmonary edema or pleural effusion
排除标准
- •Need for inotropic or vasopressive agents
- •Use of intravenous (IV) contrast media
- •Acute coronary syndrome
- •Need of dialysis
- •Severe co-morbidity
- •Contra-indications for anticoagulation
- •Pregnancy
研究组 & 干预措施
ultrafiltration group
Active Comparator
干预措施: ultrafiltration (Procedure)
diuretics group
Active Comparator
干预措施: diuretics (Drug)
结局指标
主要结局
Incidence of AKI and determining factors in patients with acute decompensated heart failure with treated with ultrafiltration versus diuretics
时间窗: at 6 months
次要结局
- determination of the value of Neutrophil gelatinase-associated lipocalin (NGAL) to predict AKI in acute decompensated heart failure (vs creatinine, Cystatin C,measured urinary creatinine clearance) in patients treated with diuretics vs ultrafiltration.(at 48h after treatment start)
- Combined endpoint of mortality/rehospitalisation-urgent outpatient visit due to heart failure(at 6 months)
- Kidney function measured by creatinine(after 28 days and 6 months)
研究者
研究点 (1)
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