NL-OMON39690已完成不适用
Antibiotic treatment alone for children with acute appendicitis; a prospective cohort study part of the Antibiotic versus Primary Appendectomy for Children with acute appendicitis; the APAC trial. - Antibiotic treatment alone for acute simple appendicitis in children
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 50
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 2 至 17（—）
入选标准
- •* Written Informed consent obtained
- •* Age 7-17 years
- •* Radiologically confirmed simple appendicitis, defined as:
- •a. Clinical findings:
- •i. Unwell, but not generally ill
- •ii. Localized tenderness in the right iliac fossa region
- •iii. Normal/hyperactive bowel sounds
- •iv. No guarding
- •v. No mass palpable
- •b. Ultrasonography:
- •i. Incompressible appendix with an outer diameter of *6 mm
- •ii. Hyperaemia within the appendiceal wall
- •iii. With or without faecolith
- •iv. Infiltration of surrounding fat
- •v. No signs of perforation
- •vi. No signs of intra abdominal abscess/phlegmone
排除标准
- •The following patients will be excluded from participating in this study:
- •1. Patients with severe general illness at time of presentation:
- •a. Generalized peritonitis defined as:
- •Diffuse inflammation of the peritoneum with clinical signs consisting of increasing abdominal pain, generalized tenderness, diffuse abdominal rigidity, sinus tachycardia, signs of paralytic ileus
- •b. Severe sepsis or septic shock, as defined by the international paediatric sepsis consensus conference [36]. See attachment 1.
- •c. Signs of complex appendicitis;2. Patients with serious associated conditions or malformations such as:
- •a. Congenital or acquired cardiac or pulmonary disease with significant hemodynamic consequences
- •b. Immunodeficiency
- •c. Malignancy
- •d. Homozygous sickle cell disease
- •e. Metabolic disorders;3. Patient with documented type 1 allergy to the antibiotics used;4. Children with faecolith on ultrasound
研究者
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