Study to compare the extent to which brain matter is normal with a well known score in patients with cancer at posterior part of brain between two groups:those that receive Mannitol ( drug that has been shown to decrease brain swelling in other studies) with those that receive normal saline
Phase 3
Completed
- Conditions
- Health Condition 1: D496- Neoplasm of unspecified behavior of brain
- Registration Number
- CTRI/2019/05/018973
- Lead Sponsor
- Post Graduate Institute of Medical Education and Research
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 66
Inclusion Criteria
Any patient undergoing Cerebello-pontine Angle tumor resection in supine position, Age between 18 to 65 years, ASA I and II patients
Exclusion Criteria
Patient refusal for consent, Surgery performed in sitting position, Patients on preoperative osmotic therapy, Patients with severe systemic illness such as renal failure, hepatic failure, congestive heart failure, coronary artery disease or severe valvular disease
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To compare Brain Relaxation Score between two groups by surgeonsTimepoint: Just before dura is opened and just after dura is opened
- Secondary Outcome Measures
Name Time Method To compare Brain Relaxation Score between two groups by anesthetistsTimepoint: Before and after dural opening;To note any perioperative complications in both the groupsTimepoint: During surgery and within 24 hours post surgery;To note total duration of hospital stay in both the groupsTimepoint: Total duration of hospital stay;To study and compare the hemodynamic parameters between two groupsTimepoint: Every 2 hours;To study and compare the serum electrolytes and serum osmolarity between two groupsTimepoint: Baseline, 1 hour post intervention and closure