Effects of Vitamin D Supplementation on Muscle Function Among Grave's Disease Patients
- Conditions
- Graves Disease
- Registration Number
- NCT06451016
- Lead Sponsor
- Frontier Medical and Dental College, Abbotabad
- Brief Summary
Introduction:
A deficit in vitamin D may be involved in the development and presentation of Graves' disease (GD). Lack of vitamin D and GD are linked to deteriorating quality of life (QoL) and weakening of the muscles. Our goal was to look at the possible advantages of vitamin D supplementation for the improvement of thyroid-related QoL and muscle function in GD patients, as well as the possible drawbacks of anti-thyroid drugs (ATD).
Methodology:
A multicenter randomized controlled experiment with single-blinding was carried out with 48 patients who had been diagnosed with Graves' illness. The participants were split into two groups n=24 patients in each group. In addition to standard ATD, Group A received either 70 μg (2800 IU) of vitamin D daily or a corresponding placebo. Investigator measured muscular function and isometric strength at baseline, three, and nine months.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 48
- Grave's Disease
- either starting or about to start anti-thyroid medication (ATD)
- Chronic granulomatous disease
- hypercalcemia
- poor renal function (eGFR < 45 ml/min)
- the presence of malignant disease
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Muscle Strength base line and after 3months Hand Grip strength was measured using dynamometer
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (2)
Frontier Medical and Dental College
🇵🇰Abbottābād, KPK, Pakistan
Frontier Dental
🇵🇰Abbottābād, Sindh, Pakistan
Frontier Medical and Dental College🇵🇰Abbottābād, KPK, Pakistan