Effects of Vitamin D Supplementation on Muscle Function Among Grave's Disease Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 48
- 试验地点
- 3
- 主要终点
- Muscle Strength
研究概览
简要总结
Introduction:
A deficit in vitamin D may be involved in the development and presentation of Graves' disease (GD). Lack of vitamin D and GD are linked to deteriorating quality of life (QoL) and weakening of the muscles. Our goal was to look at the possible advantages of vitamin D supplementation for the improvement of thyroid-related QoL and muscle function in GD patients, as well as the possible drawbacks of anti-thyroid drugs (ATD).
Methodology:
A multicenter randomized controlled experiment with single-blinding was carried out with 48 patients who had been diagnosed with Graves' illness. The participants were split into two groups n=24 patients in each group. In addition to standard ATD, Group A received either 70 μg (2800 IU) of vitamin D daily or a corresponding placebo. Investigator measured muscular function and isometric strength at baseline, three, and nine months.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Grave's Disease
- •either starting or about to start anti-thyroid medication (ATD)
排除标准
- •Chronic granulomatous disease
- •hypercalcemia
- •poor renal function (eGFR < 45 ml/min)
- •the presence of malignant disease
结局指标
主要结局
Muscle Strength
时间窗: base line and after 3months
Hand Grip strength was measured using dynamometer
次要结局
未报告次要终点
研究者
Dr Saif ur Rehman
Professor
Frontier Medical and Dental College, Abbotabad