The Role of Netrin -1 in Acute Coronary Syndrome

Not Applicable

Completed

• Conditions: Acute Coronary Syndrome
• Interventions: Other: netrin-1 value on admission to hospital

• Registration Number: NCT04027127
• Lead Sponsor: Aksaray University Training and Research Hospital

Brief Summary

In our study, Netrin -1; We found that patients with ACS increased at the time of admission, decreased TIMI 3 flow after angiography, and higher risk groups in high risk groups such as TIMI and GRACE were found to have higher Netrin-1 levels.

Detailed Description

Not available

Study Timeline

• Study Start: 2013-09-15
• Primary Completion: 2014-08-15
• Study Completion: 2018-06-15
• Study First Submitted: 2019-06-18
• Status Verified: 2019-07
• Study First Submitted QC: 2019-07-18
• Last Update Submitted: 2019-07-18
• Study First Posted: 2019-07-19
• Last Update Posted: 2019-07-19

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 238

Inclusion Criteria

• Patients over the age of 18
• diagnose ACS
• patients undergoing angiography

Exclusion Criteria

• CVE history
• Neurological disease
• Pregnancy and Lactation
• Liver failure
• Diagnosed malignity
• Use of anticonvulsant and nephrotoxic medication
• Chronic kidney disease
• Not having angiography
• Developing acute renal failure after angiography
• Patients who rejected to participate were excluded.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
ACS GRUP	netrin-1 value on admission to hospital	Demographic characteristics, history, vital signs, laboratory findings, coronary angiography (CAG) and echocardiography (ECO) findings of the patients were recorded. Netrin-1 levels were studied with blood collected at the hospital and 6-8 hours after CAG. CAG results were evaluated by TIMI flow. The patients were divided into two groups with and without TIMI 3 flow and Netrin-1 levels were compared. GRACE (Global Registry of Acute Coronary Events) and TIMI (Thrombolysis in Myocardial Ischemia) clinical risk assessments were performed and Netrin-1 values were compared.
plasebo grup	netrin-1 value on admission to hospital	It consisted of those without any disease and netri-1 values at admission were compared with the uptake patient group.

Primary Outcome Measures

Name	Time	Method
serum netrin-1 value	30 minute	Netrin-1 in plasma was measured by enzyme-linked immunosorbent assay (ELISA) (Mybıosource MBS044526 ) All assays were performed in duplicate. Plasma Netrin-1 is expressed in picograms (pg) per mg.