Therapeutic Effect Of Luteolin Natural Extract Versus Its Nanoparticles On Tongue Squamous Cell Carcinoma Cell Line
- Registration Number
- NCT03288298
- Lead Sponsor
- Cairo University
- Brief Summary
In vitro study to examine whether luteolin and nano-luteolin exert an inhibitory effect on tongue squamous cell carcinoma cell line by inducing apoptosis, and to assess if nano-luteolin has more efficient apoptotic activity than luteolin on tongue squamous cell carcinoma cell line.
- Detailed Description
This study is conducted to examine whether luteolin and nano-luteolin exert an inhibitory effect on tongue squamous cell carcinoma cell line by inducing apoptosis, and to assess if nano-luteolin has more efficient apoptotic activity than luteolin on tongue squamous cell carcinoma cell line. The primary outcome is apoptosis, while the secondary outcome is cell viability.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 4
Inclusion Criteria
- Squamous cell carcinoma cell lines (OSCC, TSCC and HNSCC).
- Luteolin 5,7,3',4'-tetrahydroxy-flavone (MeSH term).
- Application of luteolin as a chemotherapeutic drug.
Read More
Exclusion Criteria
- Any cancer cell line other than OSCC, TSCC and HNSCC cell lines.
- Luteolin glycosides.
Read More
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description nano-luteolin nano-luteolin nano-particles derived from a natural extract luteolin luteolin luteolin a natural extract derived flavinoids
- Primary Outcome Measures
Name Time Method gene expression of Caspase 3 to detect apoptosis 6 hours fold-changes
- Secondary Outcome Measures
Name Time Method cell viability 6 hours micromolar