Therapeutic Effect Of Luteolin Natural Extract Versus Its Nanoparticles On Tongue Squamous Cell Carcinoma Cell Line: In Vitro Study
试验速览
- 阶段
- 早期 1 期
- 入组人数
- 4
- 主要终点
- gene expression of Caspase 3 to detect apoptosis
研究概览
简要总结
In vitro study to examine whether luteolin and nano-luteolin exert an inhibitory effect on tongue squamous cell carcinoma cell line by inducing apoptosis, and to assess if nano-luteolin has more efficient apoptotic activity than luteolin on tongue squamous cell carcinoma cell line.
详细描述
This study is conducted to examine whether luteolin and nano-luteolin exert an inhibitory effect on tongue squamous cell carcinoma cell line by inducing apoptosis, and to assess if nano-luteolin has more efficient apoptotic activity than luteolin on tongue squamous cell carcinoma cell line. The primary outcome is apoptosis, while the secondary outcome is cell viability.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Squamous cell carcinoma cell lines (OSCC, TSCC and HNSCC).
- •Luteolin 5,7,3',4'-tetrahydroxy-flavone (MeSH term).
- •Application of luteolin as a chemotherapeutic drug.
排除标准
- •Any cancer cell line other than OSCC, TSCC and HNSCC cell lines.
- •Luteolin glycosides.
研究组 & 干预措施
luteolin
a natural extract derived flavinoids
干预措施: luteolin (Drug)
nano-luteolin
nano-particles derived from a natural extract luteolin
干预措施: nano-luteolin (Drug)
结局指标
主要结局
gene expression of Caspase 3 to detect apoptosis
时间窗: 6 hours
fold-changes
次要结局
- cell viability(6 hours)
研究者
Safaa Elbaz
Assistant Lecturer, Oral and Maxillofacial Pathology, BUE
Cairo University