Acute Exercise Effect on Neurocognitive Function Among Cognitively Normal Late-Middle-Aged Adults With/Without Generic Risk of Alzheimer's Disease: The Moderation Role of Exercise Volume and Apolipoprotein E Genotype
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 51
- 试验地点
- 1
- 主要终点
- Stroop task: Accuracy
研究概览
简要总结
This study explores the acute exercise effect on neurocognitive function and also its potential moderators in an exercise setting and Apolipoprotein E (APOE) genetic risk.
详细描述
Acute exercise has emerged as a modifier to multiple aspects of cognitive function; however, its effect on populations with different risks of Alzheimer's disease (AD) and the role of exercise variance and APOE genotype within the effect reminds underestimated. The current study aimed to examine the acute exercise effect on neurocognitive function from behavioral and neuroelectric perspectives among cognitively normal late-middle-aged adults. Additionally, we determined whether variations in exercise intensity and duration and the presence of the APOE ɛ4 allele modulated the effect.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Factorial
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 50 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Adults aged between 50 and 70 years old
- •Normal or corrected-to-normal vision based on the minimal 20/20 standard
- •Cognitively normal as mini-mental state examination scores (MMSE) > 26
排除标准
- •Neurological or psychiatric disorders
- •Cardiovascular disease
- •Risk of cardiovascular fitness assessment based on the Physical Activity Readiness Questionnaire (PAR-Q)
- •Red-green color blindness.
研究组 & 干预措施
Low-intensity with longer duration (40-min) exercise (LI-40)
The participants were instructed to complete a volume-matched low-intensity with longer duration (40-min) exercise (LI-40) treatment.
干预措施: LI-40 (Behavioral)
High-intensity with shorter duration (16-min) exercise (HI-16)
The participants were instructed to complete a volume-matched high-intensity with shorter duration (16-min) exercise (HI-16) treatment.
干预措施: HI-16 (Behavioral)
Control treatment (CON)
The participants in the control treatment (CON) were instructed to complete book reading for 30-min.
Moderate-intensity with 30 min exercise (MI-30)
The participants were instructed to complete a volume-matched moderate-intensity with 30 min exercise (MI-30) treatment.
干预措施: MI-30 (Behavioral)
结局指标
主要结局
Stroop task: Accuracy
时间窗: Participants were required to complete the Stroop task approximately 30 min following the cessation of each acute exercise treatment or the 30-min reading.
A computerized Stroop task was used to assess participants' inhibitory control and basic information processing. The accuracy was calculated for the second behavioral index.
Event-related potential: P3 amplitude
时间窗: Participants were required to complete the Stroop task while EEG activity was continuously recorded approximately 30 min following the cessation of each acute exercise treatment or the 30-min reading.
The event-related potential from parietal electrodes (i.e., P3, Pz, and P4) were initially outputted for the mean P3 amplitude; the averaged mean P3 amplitudes from parietal electrodes was then calculated as the neuroelectrical indices.
Stroop task: Response time
时间窗: Participants were required to complete the Stroop task approximately 30 min following the cessation of each acute exercise treatment or the 30-min reading.
A computerized Stroop task was used to assess participants' inhibitory control and basic information processing. The response time of the correct responses was calculated for the first behavioral index.
次要结局
未报告次要终点
研究者
Yu-Kai Chang
Proffessor
National Taiwan Normal University