NL-OMON47646已完成不适用
Cardiovascular Disease in Children with chronic inflammation - CDC study (cardiovascular disease in children)
niversitair Medisch Centrum Utrecht0 个研究点目标入组 116 人开始时间: 待定最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 116
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 12 至 64（—）
入选标准
- •General criteria for all groups:
- •* 12-19 years of age ;Obese adolescents:
- •Definition according to the international standards of the International Obesity Task Force, see Cole et al, BMJ, 2000. ;JIA adolescents:
- •* Polyarticular course JIA, including polyarticular JIA and extended oligoarticular JIA, rheumafactor negatieve. These patients often suffer from lifelong rheumatic disease, and are therefore at risk for early atherosclerosis.
- •* More than 1 year after diagnosis. In first year of disease, patients undergo multiple study procedures, causing a burden on patients. In order to reduce the general burden, this study will focus on patients after their first year of disease.
- •* BMI-SD < 2 (no obese children). ;Corrected aortic arch anomalies adolescents:
- •* Corrected aortic arch anomalies, i.e. hypoplastic aortic arch, coarctatio aortae, interrupted aortic arch. These patients are at risk for hypertension and early atherosclerosis.
- •* BMI-SD (standard deviation from BMI corrected for age and sex) < 2, to prevent including obese children in this group, to prevent obesity being a confounder in later analysis. ;Cystic fibrosis adolescents:
- •- Established cystic fibrosis, all mutations.
- •- BMI-SD < 2, to prevent inclusion of obese children so that obesity cannot be a confounder in later analysis. ;Corrected ASD adolescents:
- •* Corrected ASD.
- •* No other cardiac anomalies.
- •* BMI-SD < 2, to prevent inclusion of obese children so that obesity cannot be a confounder in later analysis.
- •NB. ASD correction < age 1 year has an excellent prognosis and is not associated with enhanced risk of early atherosclerosis.
排除标准
- •A potential subject who meets any of the following criteria will be excluded from participation in this study:
- •* Intoxication (smoking, drug-use)
- •* Acute illness (fever)
- •* Mental retardation
- •* Claustrophobia
- •* A history of allergic reactions to MR contrast fluids
- •* Implanted electronic devices (i.e. pacemaker, internal cardioverter-defibrillator, cochlear implants, nerve- and bone stimulators)
- •* Subjects with ferromagnetic clips in brain, eyes or lungs
- •* A known reduced kidney function (GFR< 60 ml/min/1.73m2)
- •* Pregnancy
- •* Subjects who do not wish to be informed about abnormal findings of the cardiovascular MRI
研究者
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