Cardiovascular Disease in Children with chronic inflammation - CDC study (cardiovascular disease in children)

niversitair Medisch Centrum Utrecht0 sites116 target enrollmentTBD

Overview

No summary available.

Registry

who.int

Start Date

TBD

End Date

June 25, 2019

Last Updated

2 years ago

Study Type

Observational invasive

Sponsor

niversitair Medisch Centrum Utrecht

•General criteria for all groups:
•\* 12\-19 years of age ;Obese adolescents:
•Definition according to the international standards of the International Obesity Task Force, see Cole et al, BMJ, 2000\. ;JIA adolescents:
•\* Polyarticular course JIA, including polyarticular JIA and extended oligoarticular JIA, rheumafactor negatieve. These patients often suffer from lifelong rheumatic disease, and are therefore at risk for early atherosclerosis.
•\* More than 1 year after diagnosis. In first year of disease, patients undergo multiple study procedures, causing a burden on patients. In order to reduce the general burden, this study will focus on patients after their first year of disease.
•\* BMI\-SD \< 2 (no obese children). ;Corrected aortic arch anomalies adolescents:
•\* Corrected aortic arch anomalies, i.e. hypoplastic aortic arch, coarctatio aortae, interrupted aortic arch. These patients are at risk for hypertension and early atherosclerosis.
•\* BMI\-SD (standard deviation from BMI corrected for age and sex) \< 2, to prevent including obese children in this group, to prevent obesity being a confounder in later analysis. ;Cystic fibrosis adolescents:
•\- Established cystic fibrosis, all mutations.
•\- BMI\-SD \< 2, to prevent inclusion of obese children so that obesity cannot be a confounder in later analysis. ;Corrected ASD adolescents:

•A potential subject who meets any of the following criteria will be excluded from participation in this study:
•\* Intoxication (smoking, drug\-use)
•\* Acute illness (fever)
•\* Mental retardation
•\* Claustrophobia
•\* A history of allergic reactions to MR contrast fluids
•\* Implanted electronic devices (i.e. pacemaker, internal cardioverter\-defibrillator, cochlear implants, nerve\- and bone stimulators)
•\* Subjects with ferromagnetic clips in brain, eyes or lungs
•\* A known reduced kidney function (GFR\< 60 ml/min/1\.73m2\)
•\* Pregnancy