Intensity Dependent Clinical Effects of a Task-oriented Upper Limb Training in Multiple Sclerosis
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Multiple Sclerosis
- Sponsor
- Hasselt University
- Enrollment
- 21
- Locations
- 2
- Primary Endpoint
- Nine Hole peg test
- Status
- Completed
- Last Updated
- 6 years ago
Overview
Brief Summary
An adequate upper limb function is crucial to independently perform Activities of Daily Living (ADL). Persons with neurological diseases often experience upper limb dysfunction. Upper limb function in Multiple Sclerosis (MS) is highly prevalent, increasing with overall disability level, while the detrimental impact on ADL is higher than in stroke, given that symptoms often occur bilaterally. In contrast to stroke, it is unknown whether similar rehabilitation principles and effect sizes apply in MS given that this progressive neurodegenerative disease is characterized by multiple lesions and atrophy of brain structures. To date, optimal therapy dosage of upper limb rehabilitation programs are not known in the MS literature neither were characteristics of responders identified.
The aim of this explorative study is to investigate the intensity dependent clinical effects of a task-oriented upper limb training in persons with MS with different upper limb disability levels.
Investigators
Peter Feys
Professor
Hasselt University
Eligibility Criteria
Inclusion Criteria
- •Age \> 18 years
- •Diagnosis of MS (McDonald criteria)
- •Progressive type of MS (primary or secondary progressive MS)
- •A score 1 or more on the performance scale: item hand function
Exclusion Criteria
- •A relapse or relapse-related treatment within the last 3 months prior to the study
- •Complete paralysis of both upper limbs
- •Marked or severe intention tremor (Fahn's tremor rating scale \> 3)
- •Other medical conditions interfering with the upper limb function (ortopaedic or rheumatoid impairment)
- •Severe cognitive or visual deficits interfering with testing and training
Outcomes
Primary Outcomes
Nine Hole peg test
Time Frame: 8 weeks
Manual dexterity
Manual Ability Measure-36
Time Frame: 8 weeks
Questionnaire about perceived ADL performance
Isometric hand grip
Time Frame: 8 weeks
Isometric hand grip
pinch grip strength
Time Frame: 8 weeks
pinch grip strength
Training tolerance
Time Frame: daily through study compeletion
Questionnaire of training tolerance and possible adverse effects
Secondary Outcomes
- Rydel Seiffer Tuning fork(8 weeks)
- Test d'Évaluation des Membres Supérieurs des Personnes Âgées (TEMPA)(8 weeks)
- Accelerometers (Actigraph)(8 weeks)
- Virtual Peg Insertion Test(8 weeks)
- Symbol digit modalities test(8 weeks)
- Action Research Arm Test(8 weeks)
- Box and block test(8 weeks)
- Motricity Index(8 weeks)
- Muscle fatigue indices(8 weeks)
- Tactile sensitivity in the fingers Semmens-Weinstein monofilaments(8 weeks)