Effect of Haemodialysis on the Efficacy of Antiplatelet Agents
试验速览
- 阶段
- 不适用
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- using light transmittance aggregometer to detect whether haemodialysis can affect the efficacy of antiplatelet agents
研究概览
简要总结
The main purpose of our study is to investigate whether haemodialysis itself affects the efficacy of antiplatelet drugs and the effects of two different types of dialysis membranes (polysulfone membranes and polyamide membranes) on antiplatelet efficacy. A total of 60 patients with ESRD and under dual-antiplatelet treatmen for at least 5 days will be enrolled and divided into the Clopidogrel group (clopidogrel 75mg qd;aspirin 100mg qd, n=30) and the Ticagrelor group (ticagrelor 90mg bid; aspirin 100mg qd, n=30). All included patients will receive haemodialysis by two different types of dialysis membrane.Platelet aggregation of venous blood from all patients will be detected by LTA and VerifyNow immediately before and after two times of haemodialysis.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •diagnosis of coronary heart disease including stable angina, unstable angina, acute myocardial infarction
- •taking dual antiplatelet drugs (clopidogrel 75mg qd + aspirin 100mg qd or ticagrelor 90 mg,bid + aspirin 100 mg,qd) at least 5 days
- •haemodialysis patients
- •sign informed consent
排除标准
- •platelet count>450 × 10 9 /L or <100 × 10 9 /L
- •using IIb / IIIa inhibitor drugs within 10days
- •taking nonsteroidal anti-inflammatory drugs other than aspirin
- •hemorrhagic disease
- •allergic to aspirin, ticagrelor or clopidogrel
- •other factors may affect the results of this study
结局指标
主要结局
using light transmittance aggregometer to detect whether haemodialysis can affect the efficacy of antiplatelet agents
时间窗: collecting blood within 10 miuntes before and after haemodialysis;detecting them within 2 hours
intravenous blood collection with anticoagulant tube before and after haemodialysis respectively ；using light transmittance aggregometer to detect adenosine diphosphate induced platelet aggregation rate and arachidonic acid induced platelet aggregation rate within two hours after blood collection;;compare the outcome of light transmittance aggregometer with VerifyNow
次要结局
- using VerifyNow to detect whether haemodialysis can affect the efficacy of antiplatelet agents(collecting blood within 10 miuntes before and after haemodialysis;detecting them within 2 hours)