The effect of propofol based anaesthesia versus sevoflurane based anaesthesia on tumour marker levels after gall bladder cancer surgery.
Phase 4
- Conditions
- Health Condition 1: C23- Malignant neoplasm of gallbladder
- Registration Number
- CTRI/2024/02/063208
- Lead Sponsor
- Dr. Sohan Lal Solanki
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
i.Adult patients 18 years and above
ii.Patients posted for radical cholecystectomy surgeries
iii.American Society of Anesthesiologists (ASA) grade I-II
Exclusion Criteria
i.Patients with severe uncontrolled hepatic, renal, pulmonary, CNS or cardiac diseases
ii.Pregnancy and lactation
iii.Patients posted for revision cholecystectomy surgery
iv.History of allergy to eggs or study drugs
v.Patient refusal
Study & Design
- Study Type
- PMS
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Measurement of angiogenic serum VEGF-C and TGF-ß levels in the blood.Timepoint: 2 hours prior to induction of anaesthesia and 24 hours after the surgery.
- Secondary Outcome Measures
Name Time Method ength of hospital stayTimepoint: After surgery and upto discharge or death.;Length of intensive care unit stayTimepoint: After the admission into intensive care unit to discharge or death.;Morbidity as per Clavien-Dindo classificationTimepoint: upto 30 days after surgery;Postoperative nausea and vomitingTimepoint: After admission into recovery room and upto 24 hours after surgery;Postoperative pain scores and use of opioids for pain reliefTimepoint: After admission into recovery room and upto 24 hours after surgery;Readmission in the hospitalTimepoint: after discharge upto 30 days after surgery;Recurrent free survival and overall survivalTimepoint: One year after the surgery