Improving Memory in Alzheimer's Disease with Noninvasive Brain Stimulation

Not Applicable

Recruiting

• Conditions: Alzheimer Disease

• Registration Number: NCT06094192
• Lead Sponsor: Boston University Charles River Campus

Brief Summary

The investigators will evaluate the theory that Alzheimer's disease-related memory impairment derives from the inefficient orchestration of rhythmic activity at the level of large-scale cortical networks. The results as expected to elucidate AD-related pathophysiology and set groundwork for the development of drug-free interventions for improving memory in AD and related dementias.

Detailed Description

The investigators hypothesize that AD-related memory impairments emerge from large-scale functional dysconnectivity, and by stimulating the brain noninvasively with extremely weak levels of electrical current, the investigators may be able to re-synchronize connectivity and stabilize or improve memory and cognitive function, measured behaviorally. The experimental intervention involves the application of low-intensity, high-definition, transcranial electrical current stimulation while subjects perform a variety of computer-based tasks that probe memory and cognitive function.

Study Timeline

• Study First Submitted: 2023-10-14
• Study First Submitted QC: 2023-10-19
• Study First Posted: 2023-10-23
• Study Start: 2023-12-20
• Status Verified: 2024-06
• Last Update Submitted: 2024-11-06
• Last Update Posted: 2024-11-07
• Primary Completion: 2028-05-31
• Study Completion: 2028-05-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 204

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Memory performance (sham stimulation condition)	Time Frame: Memory performance data is collected during sham brain stimulation and reported 1 year later	The accuracy of task performance on memory test
Memory performance (active stimulation condition)	Time Frame: Memory performance data is collected during active brain stimulation and reported 1 year later	The accuracy of task performance on memory test

Trial Locations

Locations (1)

677 Beacon St. Room 308; 🇺🇸 Boston, Massachusetts, United States