Improving Memory in Alzheimer's Disease with Noninvasive Brain Stimulation
- Conditions
- Alzheimer Disease
- Interventions
- Device: High definition transcranial electrical current stimulation
- Registration Number
- NCT06094192
- Lead Sponsor
- Boston University Charles River Campus
- Brief Summary
The investigators will evaluate the theory that Alzheimer's disease-related memory impairment derives from the inefficient orchestration of rhythmic activity at the level of large-scale cortical networks. The results as expected to elucidate AD-related pathophysiology and set groundwork for the development of drug-free interventions for improving memory in AD and related dementias.
- Detailed Description
The investigators hypothesize that AD-related memory impairments emerge from large-scale functional dysconnectivity, and by stimulating the brain noninvasively with extremely weak levels of electrical current, the investigators may be able to re-synchronize connectivity and stabilize or improve memory and cognitive function, measured behaviorally. The experimental intervention involves the application of low-intensity, high-definition, transcranial electrical current stimulation while subjects perform a variety of computer-based tasks that probe memory and cognitive function.
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 204
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description active stimulation High definition transcranial electrical current stimulation Memory performance data is collected during active brain stimulation and reported 1 year later sham stimulation High definition transcranial electrical current stimulation Memory performance data is collected during sham brain stimulation and reported 1 year later
- Primary Outcome Measures
Name Time Method Memory performance (sham stimulation condition) Time Frame: Memory performance data is collected during sham brain stimulation and reported 1 year later The accuracy of task performance on memory test
Memory performance (active stimulation condition) Time Frame: Memory performance data is collected during active brain stimulation and reported 1 year later The accuracy of task performance on memory test
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
677 Beacon St. Room 308
🇺🇸Boston, Massachusetts, United States