Single-arm phase II trial of the combination chemotherapy of 5-fluorouracil, Folinic acid, and oxaliplatin as 1st line treatment in adenocarcinoma of unknown primary

Korea Cancer Center Hospital0 个研究点目标入组 32 人开始时间: 待定最近更新: 2019年3月11日

适应症

试验速览

暂无简介。

•Newly diagnosed adenocarcinoma of unknown primary origin (histologic diagnosis)
•Tests described below to find out the origin or cancer should be performed.'
•complete blood count, chemistry, urine analysis
•chest & abdomen-pelvis enhanced CT
•Mammography in case of female patient (Breast MRI if clincally suspected breast cancer)
•Endoscopy (Stomach, colon)
•Other nessesary tests about the suspected primary
•Exclusion of suspected origin through review of histopathologic findings as follows:
•Estrogen or progesterone receptor positive in female patients
•TTF (Thyroid transcription factor 1) positive
•PSA (Prostate specific antigen) positive in male patients
•Age: over 20 years old

•Axillary lymph node metastasis in female patient
•papillary adenocarcinoma of abdominal cavity in female patient
•bone adenocarcinoma with elevating PSA in male patient
•Potentially resectable metastatic cancer
•Brain metastasis
•History of surgery of malignant tumor
•cancer other than adenocarcinoma (ex. leiomyosarcoma, lymphoma) or secondary malignancy.
•(basal cell skin cacner or uterine cervix intraepithelial cell carcinoma that were previously successfully treated were exceptions)

发起方

Korea Cancer Center Hospital