Predictive Value of Circulating Tumor DNA (ctDNA) for no Evidence of Disease (NED) Status in Metastatic Colorectal Cancer (mCRC) and Its Utility in Guiding Therapeutic Intervention: an Open-label, Prospective, Phase II Cohort Study
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 110
- 试验地点
- 1
- 主要终点
- Relapse-free survival (RFS) time
研究概览
简要总结
The goal of this clinical trial is to detect the prognostic value of longitudinal monitoring circulating tumor DNA (ctDNA) for no evidence of disease (NED) status in metastatic colorectal cancer (mCRC) patients and its utility in guiding therapeutic intervention. The main questions it aims to answer are:
- Whether ctDNA monitoring could evaluate NED status ahead of normal radiologic monitoring. What about the concordance of evaluating NED status by ctDNA monitoring compared with normal radiologic monitoring?
- Whether the patients with ctDNA positive status could benefit from early therapeutic intervention.
Patients who receive any kinds of therapies with the aim of NED and are confirmed by clinical and radiologic examination will go through longitudinal ctDNA monitoring. According to the results of ctDNA monitoring, the patients will be divided into ctDNA positive group and ctDNA negative group. Patients in ctDNA positive group will receive individual therapeutic plan decided by the investigator. Patients in ctDNA negative group will receive regular examinations. When radiologic recurrences are confirmed, the patients will be re-evaluated for a second opportunity of radical resection.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age > 18 years old. Both male and female are eligible.
- •Late stage metastatic colorectal adenocarcinoma diagnosed by histology or cytology.
- •With potential opportunity of achieving NED status (including liver metastasis, lung metastasis, solitary lymph node metastasis, ovarian metastasis or focal pelvic metastasis), regardless of neo-adjuvant therapy or transforming therapy.
- •Patients who are intended for focal therapy, radical surgery, focal radiotherapy, radiofrequency ablation or interventional therapy (anhydrous alcohol injection or cryotherapy)
- •Eastern Cooperative Oncology Group (ECOG) grade 1-
- •Approve the informed consent.
- •Available for tumor sample obtained by resection or aspiration.
- •Available for peripheral blood collection (10mL per tube for 2 tubes)
排除标准
- •Cannot get histologic or cytologic diagnosis.
- •Clinical tumor, node, and metastasis (cTNM) stage I-III according to the American Joint Committee on Cancer (AJCC), the 8th edition.
- •Accompany with widespread metastasis and cannot achieve NED status by focal therapy, such as bone metastasis, peritoneum metastasis, diffuse liver or lung metastasis or malignant effusion, etc.
- •Inadequate bone marrow reserve and organ function.
- •Uncontrolled or severe systemic diseases, such as uncontrolled hyperplasia, severe infection, hepatitic B virus (HBV) infection, hepatitis C virus (HCV) infection, human immunodeficiency virus (HIV) infection, etc.
- •History of alcohol or drug abuse.
- •Pregnant or lactating women.
- •Cannot get tumor sample.
结局指标
主要结局
Relapse-free survival (RFS) time
时间窗: From date of surgery until the date of first documented progression or date of death from any cause, whichever came first, assessed up to 2 years.
To detect the RFS time in metastatic colorectal cancer (mCRC) patients with no evidence of disease (NED) status who received circulating tumor DNA (ctDNA) guided therapies.
次要结局
- Overall survival (OS) time(From the date of surgery until the date of death from any cause, assessed up to 2 years.)
- The positive rate of ctDNA in mCRC patients with NED status.(Post-operation 1 month)
- The concordance index of ctDNA defined NED and radiology defined NED status.(When the clinic trail is finished, up to 2 years.)
- The rate of achieving NED status when relapses happen.(When the relapses happen, up to 2 years.)