Assessment of the Effectiveness of Low-Level Laser Therapy on the Hands of Patients With Rheumatoid Arthritis

Not Applicable

Completed

• Conditions: Rheumatoid Arthritis
• Interventions: Other: phototherapy; Other: phototherapy placebo

• Registration Number: NCT00632710
• Lead Sponsor: Federal University of São Paulo

Brief Summary

The purpose of the present study was to assess the effectiveness of low-level laser therapy on the reduction in pain and improvement in function in the hands of patients with rheumatoid arthritis

Detailed Description

Rheumatoid arthritis (RA) is a chronic inflammatory disease of unknown etiology that basically compromises the joints in a generalized, symmetrical, additive and usually progressive manner. This clinical condition includes pain and altered functionality. Low-level laser therapy (LLLT) has been studied since the 1970s with regard to its therapeutic effects. The literature suggests that it offers analgesic as well as anti-inflammatory benefits.

A number of studies carried out in the laboratory and on animals have shown that LLLT contributes toward the treatment of inflammatory joint disease. However, studies on humans with RA have yielded controversial results. A large part of the authors researched state that further randomized double-blind controlled studies should be carried out to prove the effectiveness of LLLT on RA. Thus, the aim of the present study was to assess the effectiveness of LLLT on the reduction in pain and improvement in function in the hands of patients with RA.

Study Timeline

• Study Start: 2004-07
• Primary Completion: 2005-12
• Study Completion: 2005-12
• Study First Submitted: 2008-02-07
• Status Verified: 2008-03
• Study First Submitted QC: 2008-03-04
• Last Update Submitted: 2008-03-04
• Study First Posted: 2008-03-11
• Last Update Posted: 2008-03-11

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 82

Inclusion Criteria

• patients with RA
• inflammatory condition of at least two hand joints among the wrists, proximal interphalangeal (PIP) joint and metacarpophalangeal (MCP) joint
• visual analogue scale (VAS) for pain between 3 and 8 cm during activities of daily living
• and being of either gender

Exclusion Criteria

• skin lesions at the application site
• other illnesses affecting the hands; physiotherapy for the hands in the previous three months
• joint injections in the previous three months
• change in disease-modifying anti-rheumatic drugs in the previous three months
• and change in corticosteroids in the previous month.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
b	phototherapy	laser
a	phototherapy placebo	laser placebo

Primary Outcome Measures

Name	Time	Method
pain	2 months

Secondary Outcome Measures

Name	Time	Method
function	2 months

Trial Locations

Locations (1)

Federal University of Sao Paulo; 🇧🇷 Sao Paulo, SP, Brazil