Induction and regression of dental local anasthetics- Monitoring by neurophysiologically examination by Quantitative Sensory Testing (QST) considering adrenalin as vasoconstricor and Phentolamine mesilate as vasodilator

Not Applicable

Conditions: o illness or health problem is investigated, only the effects of local anesthesia on different nerve fibers are examined

Registration Number: DRKS00016057

Lead Sponsor: Ressort Forschung und Lehre der Universitätsmedizin Mainz

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: Male

Target Recruitment: 20

Inclusion Criteria

Age 18-40 years
- Belonging ASA risk group 1, no general conditions
- Body weight = 50kg
- No use of permanent or acute medication
- No alcohol, nicotine or coffee consumption in the last 24 hours before examination
- No pain symptoms in the maxillary anterior region in the last 6 months
- No dental therapy in the maxillary anterior region before the examination
- No indication of neurological or psychiatric disorders
- No diseases affecting the somatosensitive system
- No known allergies / hypersensitivity reactions to the test substances used
- Response to the local anesthetic
- Non smoking
- No chronic alcohol consumption
- good compliance
- Sufficient knowledge of German
- Maxillary Canines - Clinically and anamnestically unremarkable, caries-free and filling-free, vital
- Parodontium in the maxillary canine region free of inflammation
- Written agreement to participate

Exclusion Criteria

- ASA Risk Group II-IV
- Present contraindications for topical anesthetics, epinephrine or Phentolamine mesilate
- Known allergies / hypersensitivity reactions to the test substances used, including allergy to sodium sulphite (antioxidant)
- Failure to respond to the respective local anesthetic
- Nicotine abuse, alcohol dependence
- Persistent pain in the last 6 months
- Any kind of general diseases
- Regular / acute medication
- History of previous problems with dental local anesthesia
- Filled / carious / non-sensitive maxillary canines
- Local inflammatory conditions and mucosal lesions of the oral cavity (such as gingivitis, parodontitis, leukoplakia, oral lichen planus, pemphigus vulgaris) or the skin in the test area
- Reference data for the lip when collecting the first QST finding
- lack of understanding of the necessary cooperation in the tests
- Scar in the test area
- Withdrawal of consent by the patient

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Decay the local anesthetic solution and attainment of initial values<br>t8: 220min after injection of the local anesthetic solution (will not be achieved by all subjects)

Secondary Outcome Measures