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临床试验/NCT03973463
NCT03973463Unknown不适用

Effects of Diet Control and Resistance Exercise Training on Obesity Adults With Knee Osteoarthritis in Pain Relief, Body Composition, Lower Limb Function and Quality of Life

Chang Gung Memorial Hospital2 个研究点 分布在 1 个国家目标入组 90 人开始时间: 2018年5月3日最近更新:
适应症

试验速览

阶段
不适用
发起方
入组人数
90
试验地点
2
主要终点
KOOS

研究概览

简要总结

The purpose of this study was to investigate the effects of obesity on knee degenerative arthritis on body composition after dietary control and elastic resistance exercise; and whether persistent exercise habits and dietary control can relieve pain and strengthen muscle strength. Improve the quality of life and the decline of other risk factors.

详细描述

Due to dietary westernization and overweight, the number of knee joint degeneration is increasing year by year. Degeneration of knee arthritis can lead to pain and not exercise, and thus other chronic diseases. When the weight loss exceeds 5.1%, the function of the knee joint can be significantly improved and low heat weight loss (1200 kcal / day) and very low heat weight loss (less than 800 kcal / day) both weight loss The results are equally good .Many studies have shown that early and mid-interventional resistance exercise can improve muscle weakness, pain and stiffness in patients with degenerative knee arthritis, and elastic resistance exercise can effectively improve lower limb function and increase physical activity in patients with knee arthritis However, there has been no research on the effects of diet control and resistance exercise training on pain relief, body composition, lower limb function and quality of life in obese knee degenerative arthritis. The purpose of this study was to explore the degenerative knee degeneration. The effect of arthritis on the composition of the body after a balanced diet calorie control and home-based low-intensity elastic resistance movement; and whether persistent exercise habits and diet control can relieve pain, strengthen muscle strength, improve quality of life and other risks The effect of factor decline. Expected to combine the diet control and home group exercise to improve the quality of life of patients with degenerative knee arthritis.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Treatment
盲法
None

入排标准

年龄范围
55 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Cases of knee joint degeneration diagnosed by orthopedics, rheumatology and immunology physicians.
  • X-ray interpretation (kellgren & Lawrence grade) grades 1 to 3 or mild to moderate patients.
  • Willing to sign written consent form.
  • Pain Index (VAS) ≧ 4/
  • Men and women over the age of
  • Body mass index (BMI) ≧ 27 kg/m^2.

排除标准

  • Unable to act on your own.
  • X-ray interpretation (kellgren & Lawrence level) is greater than level 3 or is a serious level.
  • Patients who have undergone knee arthroplasty on one or both feet.
  • Patients with terminal liver and kidney disease.
  • Those who are unable to perform physical function measurement after severe diagnosis of heart and lung disease after diagnosis by the physician.
  • High blood pressure with poor control (systolic blood pressure greater than or equal to 180 mmHg at the time of return).
  • Pregnant women or breastfeeding women.
  • Those who have coronary stents, cardiac rhythms, or other metallic substances in the body are not recommended for total body composition analysis.
  • Those with severe hip, knee, and lower back pain who are unable to perform exercise, other neuromuscular, skeletal joints, or rheumatic diseases may be exacerbated by exercise. Or those who have musculoskeletal injuries in the past six months (such as bruises, fractures, etc.).
  • Unable to cooperate with the test or halfway through the test.

结局指标

主要结局

KOOS

时间窗: Baseline and after 3 months

KOOS is based on WOMAC and covers a wider range. The score of each topic is 0-4 points. The higher the score after the conversion formula, the better the knee joint function. This study assessed changes in KOOS scores, whether it was higher than baseline after 12 weeks.

WOMAC

时间窗: Baseline and after 3 months

WOMAC is used to measure the patient's home knee function. Each question is scored using a five-point scale. The higher the score, the worse the knee function. This study assessed the amount of change in WOMAC scores, whether it was lower than baseline after 12 weeks.

Body fat percentage

时间窗: Baseline and after 3 months

Assess the amount of body fat (%) change, whether it can be less than baseline after 12 weeks

Body Mass Index

时间窗: Baseline and after 3 months

Assess the amount of Body Mass Index(kg/m\^2) change, whether it can be less than baseline after 12 weeks

waistline

时间窗: Baseline and after 3 months

Waist circumference change from baseline to 12 weeks (cm)

次要结局

  • hand grip force measurement(Baseline and 3 months)
  • Low-density cholesterol(Baseline and 3 months)
  • triglyceride(Baseline and 3 months)
  • 30 chair stand test(Baseline and 3 months)
  • total cholesterol(Baseline and 3 months)
  • 2.44m time up to go(Baseline and 3 months)

研究者

发起方
Chang Gung Memorial Hospital
申办方类型
Other
责任方
Principal Investigator
主要研究者

yenyen0411

Dietitian,Investigator

Chang Gung Memorial Hospital

研究点 (2)

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