Uppsala-Dalarna Dementia and Gait Project
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 550
- 试验地点
- 2
- 主要终点
- Conversion to dementia
研究概览
简要总结
UDDGait™ is a multidisciplinary research project with the overreaching goal of providing an aid for early identification of cognitive impairment and risk of dementia development, thereby providing a basis for adequate symptom relieving and health promoting interventions.
A new concept is investigated for this purpose: a "dual-task-test", which implies the combination of a well-established mobility test (Timed Up-and-Go, TUG) with a simultaneous verbal task (i.e. TUG dual-task, TUGdt). This type of test has been judged as a potential aid for early identification of dementia disease. More research is needed to further examine the test's validity, reliability and predictive capacity.
The overall aim is to investigate if TUGdt is useful as an aid for prediction of dementia disease. To ensure the results, the aim is also to evaluate the test's measurement properties and to generate normative reference values of healthy control persons.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 37 Years 至 94 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients undergoing memory assessment at at Uppsala University Hospital, Sweden
- •Patients undergoing memory assessment at at Falu Hospital, Sweden
- •Cognitively unimpaired individuals with a Mini Mental State Examination (MMSE) score of > 26
排除标准
- •Inability to walk three meters back and forth
- •Inability to rise from a sitting position
- •Indoor use of a walking aid
- •Current or recent hospitalization (within the last 2 weeks)
- •Need of an interpreter to communicate in Swedish
结局指标
主要结局
Conversion to dementia
时间窗: Upp to 10 years
Diagnostic information for follow-ups and eventual dates of death, all participants' medical records will be reviewed by an experienced geriatrician. Participants will be classified as having "converted" after receiving a dementia diagnosis, and as "not converted" when a diagnosis of Subjective or Mild cognitive impairment had been confirmed after baseline, or when a reversion to normal cognition had been stated. TUG and TUGdt parameters and composite indices will be examined for association with dementia incidence through Cox regression models with and without adjustment for possible confounding variables such as age, gender, and education. Possible occurrence of gender differences in associations between TUG parameters and dementia incidence will be examined. Optimal cut-off values for predictive TUG parameters (including composite indices) will be estimated. Also, sensitivity, specificity, c-statistics, and Youden's J index will be estimated.
次要结局
- Level of cognitive functioning(Upp to 10 years)
研究者
Prof. Anna Cristina Åberg
Professor
Dalarna University