Assessment of Neointimal Stent Strut Coverage and Endothelial Function After Second Generation Drug-Eluting Stent Systems

Hyogo Medical University1 site in 1 countryApril 2010

ConditionsCoronary Artery Disease Atherosclerosis

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Coronary Artery Disease
Sponsor: Hyogo Medical University
Locations: 1
Primary Endpoint: To compare coronary endothelial function after primary angioplasty.
Status: Withdrawn
Last Updated: 7 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

The purpose of this study is to compare coronary endothelium function in patients with a zotarolimus-eluting versus a sirolimus-eluting or a everolimus-eluting stents with optical coherence tomography, vasoconstriction in response to acetylcholine, and coronary biomarker level.

Registry

clinicaltrials.gov

Start Date

April 2010

End Date

February 2017

Last Updated

7 years ago

Study Type

Interventional

Study Design

Parallel

Sex

All

Investigators

Sponsor

Hyogo Medical University

Responsible Party

Principal Investigator

Kenichi Fujii

Assistant Professor

Hyogo Medical University

Eligibility Criteria

Inclusion Criteria

•Significant coronary de novo lesion (\> 70% by quantitative angiographic analysis)
•Patients with stable or acute coronary syndrome considered for coronary revascularization
•Reference vessel diameter of 2.5 to 3.5 mm by operator assessment

Exclusion Criteria

•Contraindication to anti-platelet agents
•Ostial lesion within 5 mm from ostium
•Different DES in other vessel simultaneously
•Creatinine level 2.5 mg/dL
•Left main stenosis more than 50%.
•vein graft lesion
•Triple vessel disease with stenosis more than 50% in 3 epicardial coronary arteries
•Life expectancy 1 year
•Reference vessel \< 2.5 mm or \> 4.0 mm diameter by visual
•Long lesion that require more than three stents