Analysis of the Pachychoroid Phenotype in an Asian Population
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 112
- 试验地点
- 2
- 主要终点
- Assess the chronology of choroidal changes in patients
研究概览
简要总结
The understanding of pachychoroid phenotype is incomplete. It is important to understand the risk of conversion from an uncomplicated pachychoroid phenotype to the pachychoroid disease phenotype, to guide appropriate management of these patients.
详细描述
The progression of uncomplicated pachychoroid phenotype to pachychoroid disease is not well established and the pathophysiology of these phenotypes remains unknown: specifically if the occurence of pachyvessels is the primary event, or develops secondary to the inner choroidal attenuation.
A longitudinal study of the pachychoroid phenotype will provide much needed information regarding the natural history of the pachychoroid phenotype. Secondly, a detailed chronicle of the choroidal alterations in the pachychoroid disease spectrum may yield insights into the pathogenesis, and facilitate the development of disease modulation strategies.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 45 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Presence of uncomplicated and/or non-neovascular pachychoroid phenotype in at least one eye.
- •Subfoveal choroidal thickness >300 microns on enhanced depth imaging optical coherence tomography for at least one eye
- •Male or female patients above 45 years of age
- •Willingness to undergo pupil dilation, and protocol- required procedures for both eyes
- •Willing to provide written informed consent
排除标准
- •Presence of disorders of the ocular media which interfere with visual acuity and other ocular assessments, including Spectral domain- optical coherence tomography during the study period
- •Pregnant or nursing women
结局指标
主要结局
Assess the chronology of choroidal changes in patients
时间窗: 2 years
Determine the occurence of pachyvessles is the primary event, or consequent to inner choroidal attenuation
Incidence of progression of pachychoroid phenotypes in 2 subtypes
时间窗: 2 years observation
Two subtypes of pachychoroid phenotypes: 1. from an uncomplicated pachychoroid phenotype, to a pachychoroid disease entity 2. from non neo-vascular pachychoroid disease, to neovascular pachychoroid disease
Risk factors for progression in 2 subtypes of pachychoroid phenotypes
时间窗: 2 years
1. from an uncomplicated pachychoroid phenotype, to a pachychoroidal disease entity 2. from neo-vascular pachychoroid disease, to neovascular pachychoroid disease
次要结局
未报告次要终点
研究者
Gemmy Cheung Chui Ming
Professor
Singapore National Eye Centre